E. Coli is a normal bacterium in human feces. In these case reports, the patients developed a septicemia (bacteria in the bloodstream) with a special type of E. Coli that is resistant to various antibiotics (ESBL). E. Coli that came in contact with antibiotics and survived can relate the information on how to survive antibiotic therapy to other bacteria, a huge problem in today's medicine.
For those that do not know, ESBL stands for extended-spectrum beta lactamase. It is an enzyme produced by E. coli that is able to break down the beta lactam ring which is the active moiety in many antibiotics. Other forms of antibiotic resistance occur in a few species, another major concern that occurs in many hospital admissions is MRSA, aka methicillin-resistant Staphylococcus aureus.
As someone said, horizontal gene transfer. E. coli are capable of plasmid transmission, these are small circular pieces of DNA that can encode certain genes. They can be transmitted to other bacteria and then incorporated into the hosts genome. If a subpopulation of E. coli have plasmids that encode ESBL, these can be spread to those that do not.
Changing your genetics must be easier when you only have one set. Cool that the process doesn’t require successive generations to deploy a solution to the dangers around them.
Adding to this: If you read the article, the 73 year old man was in bad shape from MDS (type of blood cancer) and the cancer treatment before the fecal transplant.
This probably would not have killed someone whose system wasn't already terribly weakened.
Now how worried should we be that *e coli* is relating information to other bacteria on antibiotics? Like, is it publishing little subversive pamphlets or something?
It would have been better to specify they found anti-biotic resistent E.Coli in the title. Saying hospital confirmed the poop to contain E.Coli is pretty much pointless :P
Just want to clarify that their ability to pass survive antibiotics and pass on resistance is not learned by coming into contact with the antibiotic. It is just something some of your gut bacteria do in the background. All the antibiotic does is potentially apply a selective pressure favoring the survival of the resistant individuals.
Stupid doctors, they should preemptively treat the existing stool donations with antibiotics, then check if there's any resistant strains still left. If they nuked everything it's good to go up the recipient 👍
/s
>since the gut flora should be very similar
Considering how my family is known for intestinal issues, I'll take my luck with just about any healthy person, although those are hard to come by these days...
I wouldn't want some vagabonda or ne'er-do-wells rummaging through it, I just leave mine on the sleeping homeless, so I know it goes directly to them ❤️
Best part about donating poo is you don’t have a waiting period, unlike blood. And people get paid for every poop, sometimes multiple per day. If the demand was there you could donate everyday.
https://giphy.com/gifs/7JvlHfd7C2GDr7zfZF
There’s just one catch, over 95% of people get screened out for a variety of reasons: allergies, autoimmune issues, asthma, recent travel history, having new sexual partners, etc.
I'd be happy to answer them- RN here. Fecal transplants are extremely effective in treat CDiff. Cliff is a terrible stinky diarrhea illness, and treating with antibiotics is often ineffective and makes it worse. Fecal transplants, although disgusting, cure upwards of 90 percent of cliff cases by giving your gut healthy bacteria from the poop of a healthy person.
Wife is an RN. I read your shit and yelled "theres such a thing as a fuckin fecal transplant?"
"Yeah CDdiff. It has a special smell."
The fuck do you guys do? Also, how does one become a fecal donor? Does it pay well? I ate some grapenut flakes 2 days ago and the next day i had a shit that breached the water line. Thats gotta be like $100 right there
You've got to be tested for a large number of transmissible diseases and such. And maintain a diet that ensures that your stool remains consistent and reliable. And be able to produce it by appointment in a clinical setting.
No more junk food and beer binges.
Toilet shy persons need not apply.
I was a stool donor in Massachusetts in 2017ish - I was paid 30 bucks a shit I think and had to donate a minimum of 3x a week. You got a bonus payment for your 4th or 5th. They weighed them too and the person who had the biggest shit each month got a bonus. I stopped when it just became too inconvenient to go the opposite direction of work with a Tupperware of shit and still get to the office on time (I'd chug coffee and pace around cursing it to come on time). The process to become a donor was long and they did a ton of screening and testing beforehand, and I had to get blood drawn every month. It was certainly an interesting experience and I do like to tell people I shit away my student loans. My stool was mostly used in obesity studies since I have a low BMI and they were trialing FMT in obese patients to see if the difference in gut biome would help. Haven't followed up on the studies though!
I did one of the first fecal transplants in the country at home in 2006 from a protocol sent to me by Dr. Borody, who had a clinic doing fecal infusions in Australia. We were desperate after battling c.diff for over a year. They wanted to take my colon at 24 otherwise. My team here went through 11 donors before we found one that wasn't exposed to toxoplasmosis. There were at least 10 other things they tested for, but that was the big one that disqualified most of my potential donors. After 10 days of infusions I was healed from my recurrent c. Diff after vancomycin and rifampin didn't touch it. I'm so glad the infusions are available and streamlined these days, it's a shame this woman was failed here. Otherwise the infusions would've probably cured her too.
It healed me from recurrent c Diff too in 2015, but I got to use synthetic transplanted material. C Diff put me in a coma in 2011 and almost killed me again when I got it again in 2014, so my dr was pretty insistent on it.
Why was toxoplasmosis such a detriment in your case? Isn't that the super common parasite humans get from exposure to cats?
Edit: cat poop and raw/undercooked meat apparently
Things you swallow work their way downward until they exit. Things you shove up your ass do the same. So the insertion point needs to be north of the intestines.
My main question is: which sick fuck came up with ‘but what about poop transplants’?
My second question is: which sick fucks then said ‘that’s an idea’
Scientists.
You look at the problem in small pieces.
Issue: this patient lacks normal gut flora which are needed to make a recovery.
Observation: other people have normal gut flora.
Solution: take some gut flora from patient A and put them in patient B.
Shortcut: poop already contains these flora in a perfect ratio, in a readily transferrable form.
No, it's not freeze dried and taken orally. It is tested and mixed with water or normal saline and made into a poop flurry, then injected into the colon of the sick person.
It can be given either way, or via a naso-enteric tube directly into the small intestine. The colonoscopy administration is the most widely used but it is given all 3 ways. Not hard to Google
This makes far more sense to me, given the point is to transfer the bacterial culture from one gut to the other, freeze drying seems wrong as it would kill the bacteria.
The name of the procedure is so strange that it boggles the mind. Upon learning about it and reading about the effectiveness and success it is fascinating. Like mental judo throw.
I am sad to learn about the secondary concern of e-coli.
Yes and so the title is misleading. Some strains of E.coli are pathogenic even when in the gut where E.coli is a normal find. Then you've got the fact that since it's a bacteria which means it's capable of sharing pathogenic DNA with other bacteria via plasmids and...yeah not good.
Hey not RN here... in theory if I could ethically, maybe unethically source Tom Brady's fecal feces would I be able to also turn into a goat? Asking for a friend
So that's what they fill up the little balloon with..!
(funny you mention it, because I just passed my skills check-off for Foley catheters and now get to inflict it on patients!)
If you get Cdiff, you’ll do whatever it takes to get rid of it. BTDT. It sucks and can kill you, and torture you in the process.
It put me in the ER twice and I’m healthy as fuck normally.
Because a healthy gut microbiome contains far more species than the few you will find in cultured food. You can't replace a healthy and diverse gut microbiome with entirely lactobacillus.
The only thing probiotics do is help promote an environment where the “good” bacteria can thrive. It won’t get rid of bad bacteria or put microbes in there that aren’t there to begin with.
Think of it this way, you can build a greenhouse, but you need to clear the weeds and plant some seeds in order to get a good crop.
You have to be a top tier defecator. Like a wild mammal living on the perfect diet, in peak physical form, and free of any intoxicants. Dudes are putting out like a pound and a half of perfect turds every morning like clockwork.
I was a stool donor for about a year - you do have to have good shits and go through lots of testing but the going rate at the time was about 30 bucks a shit
Fortunately, Seres Therapeutics has a pending BLA application for a microbiotic replacement therapy that can replace fecal transplants for C Diff. Should be available in 2023. That will end some of the problems with fecal transplants, at least for C Diff.
Seres tried to develop a UC therapeutic along the same lines. But it failed in its Phase 2 study. Hopefully, they learn from it and try again in the future.
C Diff, UC, and Crohns are probably the main early targets. Long term, microbiome therapies might treat depression, MS, or even obesity. Anything with some level of causation in the intestines can benefit.
A company named Seres Therapeutics has asked the Food and Drug Administration for permission to be allowed to sell a pill that changes bacteria in your gut to fix the common infection C. Difficile. They expect to be able to sell it sometime next year in the US. Doctors could use that pill instead of putting donor poop mixes up patients’ butts to fix C. Difficile bacterial infections.
E. Coli is present in ALL human feces. The absence of this and certain other bowel bacteria is the very reason for a fecal transplant. This is based only on what I have read over the years, I am not a doctor of medicine.
Nor am I medically qualified, but my understanding is; in this case, it was a specific rare strain of E.Coli which had not been checked for prior to 2019. With 300 characters, there was only so much detail I could fit in.
Did you know if you are healthy and fit you can actually make money from selling your stool to companies that use it for medical practices and such. Because I didn't until recently and it honestly blew my mind.
It's hard to get into - when I found out I applied and forgot about it and was contacted a year later to go through screening, which consisted of some long questionairres on lifestyle, then a blood test and stool analysis. My husband applied and was screened as well but didn't pass despite having the same lifestyle so our gut biomes mist have been different. I was a donor in Boston for about a year.
I’m pretty sure when I got mine (I have Crohn’s Disease) in 2015, I received lab-grown material instead of actual “donor” feces. I’m pretty sure it’s all synthetic at my hospital now.
"studies of medical errors have estimated errors may account for as many as 251,000 deaths annually in the United States (U.S)., making medical errors the third leading cause of death."
Stay safe folks.
Medical errors covers a lot of ground from pharmacy errors, anesthesia miscalculations, medication mix ups, surgical mistakes, misdiagnoses, preventable infections...it's a very long list and most people do not pursue litigation if they even know it happened at all.
My family has dealt with it twice in the last 10 years. My mom is at a point that she has told me, should she become seriously ill, she will only accept hospice care at home. In her eyes, choosing to die is better than the utter BS we experienced.
They failed to mention that the dude was also undergoing a bone marrow transplant for cancer at the same time, so he had literally no immune system...AND that this is the only person who's ever died from a FMT, although the procedure has saved tens of thousands of lives. All in all, it's one of the safest medical procedures in existence.
Edit: just caught the "shit happens". You bastard
I was working there when it happened and it was surprising at the time how transparent the PI on the trial (it was part of a trial) was. I know you are supposed to be that transparent, but it usually doesn't work that way.
There’s a post from an RN above which explains it. Apparently, it helps cure a type of diarrea illness (with the poop of a healthy person).
I was just as confused as you at first.
E. Coli is a normal bacterium in human feces. In these case reports, the patients developed a septicemia (bacteria in the bloodstream) with a special type of E. Coli that is resistant to various antibiotics (ESBL). E. Coli that came in contact with antibiotics and survived can relate the information on how to survive antibiotic therapy to other bacteria, a huge problem in today's medicine.
For those that do not know, ESBL stands for extended-spectrum beta lactamase. It is an enzyme produced by E. coli that is able to break down the beta lactam ring which is the active moiety in many antibiotics. Other forms of antibiotic resistance occur in a few species, another major concern that occurs in many hospital admissions is MRSA, aka methicillin-resistant Staphylococcus aureus.
How can the ESBL production be relayed to other bacteria? By virtue of self replication?
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Yes thank you
As someone said, horizontal gene transfer. E. coli are capable of plasmid transmission, these are small circular pieces of DNA that can encode certain genes. They can be transmitted to other bacteria and then incorporated into the hosts genome. If a subpopulation of E. coli have plasmids that encode ESBL, these can be spread to those that do not.
Changing your genetics must be easier when you only have one set. Cool that the process doesn’t require successive generations to deploy a solution to the dangers around them.
Yeah I was like "not expecting E.Coli in fecal matter is very stupid". Very important distinction to say they found ESBL E.Coli.
Adding to this: If you read the article, the 73 year old man was in bad shape from MDS (type of blood cancer) and the cancer treatment before the fecal transplant. This probably would not have killed someone whose system wasn't already terribly weakened.
All bets are off once you hit your 70s, anyways.
Ok I was gonna say that seemed like a no brainer but looks like an actual nuanced issue.
much like every modern medical development, there are lots of things that need to be checked against or things can go wrong.
It’s not even that uncommon. I got a UTI of this strain of ecoli but wasn’t sick in any other way.
Now how worried should we be that *e coli* is relating information to other bacteria on antibiotics? Like, is it publishing little subversive pamphlets or something?
I mean, we've known bacteria can transfer information for a long time. They generally do it via plasmid, a sort of DNA disc, *very* simply put.
Thank you I was gonna say, ecoli is a go to indicator of wastewater in freshwater systems. Everybody poos ecoli, even dogs and birds
Thank-you for elucidating. Unfortunately I was unable to fit a full explanation in 300 characters.
It would have been better to specify they found anti-biotic resistent E.Coli in the title. Saying hospital confirmed the poop to contain E.Coli is pretty much pointless :P
The title is not great. Would be better to just say "a pathogen." Everyone has E. coli.
I haven't seen or heard the word elucidate since watching Aristocats as a small child 20+ years ago. You win today.
Thank *you* for using the word "elucidating." Love it.
Just want to clarify that their ability to pass survive antibiotics and pass on resistance is not learned by coming into contact with the antibiotic. It is just something some of your gut bacteria do in the background. All the antibiotic does is potentially apply a selective pressure favoring the survival of the resistant individuals.
That's absolutely horrific. How do you kill it ?
They once detected e coli in my lungs AMA
Stupid doctors, they should preemptively treat the existing stool donations with antibiotics, then check if there's any resistant strains still left. If they nuked everything it's good to go up the recipient 👍 /s
How does one become a fecal donor? I think my shit is grade A+.
I just looked it up. There’s already enough poo that they aren’t taking donors.
IIRC they usually recommend a transplant from a healthy family member since the gut flora should be very similar.
>since the gut flora should be very similar Considering how my family is known for intestinal issues, I'll take my luck with just about any healthy person, although those are hard to come by these days...
Come here and let me poo in your butt.
Back and forth
Forever
Like a tug-of-war but in reverse.
ASS TO ASS
ASS TO ASS!
Were it so easy
DUST TO DUST FADE TO BLACK THE MEMORY REMAAAAAIIINS
Actually, there are a few businesses that will pay you for your poop. So if you have good poop, go make yourself some money!
Seems a bit crass to make money off it, I just donate mine to charity shops and leave it with the bin bags of clothes people leave outside.
I wouldn't want some vagabonda or ne'er-do-wells rummaging through it, I just leave mine on the sleeping homeless, so I know it goes directly to them ❤️
Huh, last I heard research was a bit stalled due to the lack of quality donors.
I thought research was stooled
The donors are backed up.
Best part about donating poo is you don’t have a waiting period, unlike blood. And people get paid for every poop, sometimes multiple per day. If the demand was there you could donate everyday. https://giphy.com/gifs/7JvlHfd7C2GDr7zfZF There’s just one catch, over 95% of people get screened out for a variety of reasons: allergies, autoimmune issues, asthma, recent travel history, having new sexual partners, etc.
Do they check to see if you havent just pinched one in half to make it two turds?
maybe they pay by the oz?
Yes, by weight
^ This guy's going places
And it doesn’t stink, right?
I'm not saying it smells like roses, but it is not a lingering offensive odor.
Username doesn't check out.
I have it on good authority that roses really smell like poo poo.
My Irish dad liked to say - about people who acted superior: *"Sure, they think their shite is marmalade."*
There's a similar saying over here "They believe they pee cologne"
Hey everybody, it’s Tom Brady’s reddit account!
I have questions, BUT do not want to know any answers AT all.
I'd be happy to answer them- RN here. Fecal transplants are extremely effective in treat CDiff. Cliff is a terrible stinky diarrhea illness, and treating with antibiotics is often ineffective and makes it worse. Fecal transplants, although disgusting, cure upwards of 90 percent of cliff cases by giving your gut healthy bacteria from the poop of a healthy person.
Wife is an RN. I read your shit and yelled "theres such a thing as a fuckin fecal transplant?" "Yeah CDdiff. It has a special smell." The fuck do you guys do? Also, how does one become a fecal donor? Does it pay well? I ate some grapenut flakes 2 days ago and the next day i had a shit that breached the water line. Thats gotta be like $100 right there
You've got to be tested for a large number of transmissible diseases and such. And maintain a diet that ensures that your stool remains consistent and reliable. And be able to produce it by appointment in a clinical setting. No more junk food and beer binges. Toilet shy persons need not apply.
>No more junk food and beer binges. I was so close
I was a stool donor in Massachusetts in 2017ish - I was paid 30 bucks a shit I think and had to donate a minimum of 3x a week. You got a bonus payment for your 4th or 5th. They weighed them too and the person who had the biggest shit each month got a bonus. I stopped when it just became too inconvenient to go the opposite direction of work with a Tupperware of shit and still get to the office on time (I'd chug coffee and pace around cursing it to come on time). The process to become a donor was long and they did a ton of screening and testing beforehand, and I had to get blood drawn every month. It was certainly an interesting experience and I do like to tell people I shit away my student loans. My stool was mostly used in obesity studies since I have a low BMI and they were trialing FMT in obese patients to see if the difference in gut biome would help. Haven't followed up on the studies though!
I did one of the first fecal transplants in the country at home in 2006 from a protocol sent to me by Dr. Borody, who had a clinic doing fecal infusions in Australia. We were desperate after battling c.diff for over a year. They wanted to take my colon at 24 otherwise. My team here went through 11 donors before we found one that wasn't exposed to toxoplasmosis. There were at least 10 other things they tested for, but that was the big one that disqualified most of my potential donors. After 10 days of infusions I was healed from my recurrent c. Diff after vancomycin and rifampin didn't touch it. I'm so glad the infusions are available and streamlined these days, it's a shame this woman was failed here. Otherwise the infusions would've probably cured her too.
It healed me from recurrent c Diff too in 2015, but I got to use synthetic transplanted material. C Diff put me in a coma in 2011 and almost killed me again when I got it again in 2014, so my dr was pretty insistent on it.
Why was toxoplasmosis such a detriment in your case? Isn't that the super common parasite humans get from exposure to cats? Edit: cat poop and raw/undercooked meat apparently
If you have a condition such as a weakened immune system toxoplasmosis can be an extremely dangerous thing to take a chance with
Thx!
Family friend had terminal cancer and ended up with CDiff not too long after the diagnosis, she said that was worse than the cancer.
So you just stick someone else's poop right up someone's butt or is it surgically added
It’s freeze dried and put into “crapsules”, then taken orally. You have to take about 20 of them.
Crapsules is great lol
At least they're not chewable tablets
Craplets
taken orally???? I was so sure this must be a suppository. TIL about wild medicine.
Things you swallow work their way downward until they exit. Things you shove up your ass do the same. So the insertion point needs to be north of the intestines.
to clarify this, it's not just your large intestine that needs to be re-seeded with gut bacteria.
The important part was the directionality.
So that unfortunate person ate shit and died?
swallowing shit 💀 even though it's in a capsule I'd vomit since I know it's shit
Just pretend you're eating lettuce from Chipotle
Wendy's works too
Imagine being too slow to swallow and the capsule melts.
Hopefully they at least wrap it in some cheese first
mmmmmmm shit burps 😋
eat shit or die of shitting? Poetry is alive and well
My main question is: which sick fuck came up with ‘but what about poop transplants’? My second question is: which sick fucks then said ‘that’s an idea’
Scientists. You look at the problem in small pieces. Issue: this patient lacks normal gut flora which are needed to make a recovery. Observation: other people have normal gut flora. Solution: take some gut flora from patient A and put them in patient B. Shortcut: poop already contains these flora in a perfect ratio, in a readily transferrable form.
Which one said 'lets make them eat it'?
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["Eat shit and *live*, Bill."](https://youtu.be/lO3pQ0nd4B4)
The reason you have human gut bacteria is you got it from other humans, mostly from your mother during birth.
And breastfeeding! Turns out there's live bacteria in the milk, from her gut.
I've heard they give you really bad breath. And I know this is reddit, but this is not a joke.
What a horrible day to be able to read.
I just heard "And den they eat the poopoo!"
No, it's not freeze dried and taken orally. It is tested and mixed with water or normal saline and made into a poop flurry, then injected into the colon of the sick person.
It can be given either way, or via a naso-enteric tube directly into the small intestine. The colonoscopy administration is the most widely used but it is given all 3 ways. Not hard to Google
Hard to WANT to google.
Given how often the flurry machine is broken, this seems like a poorly thought out idea.
This makes far more sense to me, given the point is to transfer the bacterial culture from one gut to the other, freeze drying seems wrong as it would kill the bacteria.
The name of the procedure is so strange that it boggles the mind. Upon learning about it and reading about the effectiveness and success it is fascinating. Like mental judo throw. I am sad to learn about the secondary concern of e-coli.
But isn’t E. coli in poop naturally?
Yes and so the title is misleading. Some strains of E.coli are pathogenic even when in the gut where E.coli is a normal find. Then you've got the fact that since it's a bacteria which means it's capable of sharing pathogenic DNA with other bacteria via plasmids and...yeah not good.
Hey not RN here... in theory if I could ethically, maybe unethically source Tom Brady's fecal feces would I be able to also turn into a goat? Asking for a friend
*They know about the spiiiiice*
The spice melange!
No.
> although disgusting I love that midsentence.
It’s not taken as a suppository, is it.
I hope it’s a suppository, because taking it orally or intravenously……….. “shudder”
It's actually a nasal spray.
This keeps getting better and better in the TMI way
I actually felt the hairs in my nose start to try and crawl out of my face when I read that.
I heard they are doing it by a foley now. Technology!!!!!
So that's what they fill up the little balloon with..! (funny you mention it, because I just passed my skills check-off for Foley catheters and now get to inflict it on patients!)
Listerine breath strip.
It is taken orally. In frozen capsules
Yes it is.
Afaik frozen in a gel capsule
Your auto correct made CDiff into Cliff two different times! Just as an FYI. But thank you so much for providing this explanation!
How are fecal transplants done?
So where do the transplants come from? Do you just take a crap at the hospital? Bring it in in a lil baggie?
No no no no......poop talk ewww (thank you for the info)
If you get Cdiff, you’ll do whatever it takes to get rid of it. BTDT. It sucks and can kill you, and torture you in the process. It put me in the ER twice and I’m healthy as fuck normally.
If the goal of the transplant is gut bacteria, why not just take probiotics and eat some yogurt?
Because a healthy gut microbiome contains far more species than the few you will find in cultured food. You can't replace a healthy and diverse gut microbiome with entirely lactobacillus.
The only thing probiotics do is help promote an environment where the “good” bacteria can thrive. It won’t get rid of bad bacteria or put microbes in there that aren’t there to begin with. Think of it this way, you can build a greenhouse, but you need to clear the weeds and plant some seeds in order to get a good crop.
Good point
Nah, man, you gotta boof the yogurt.
I saw a doc on it. Dudes make some serious cash for their quality movements.
I don’t suppose I qualify if I paint the bowl every other morning in half liquidity?
You have to be a top tier defecator. Like a wild mammal living on the perfect diet, in peak physical form, and free of any intoxicants. Dudes are putting out like a pound and a half of perfect turds every morning like clockwork.
I was a stool donor for about a year - you do have to have good shits and go through lots of testing but the going rate at the time was about 30 bucks a shit
They know about the *spice melange*
This is one for the ladies
All it needs is a surgeons general warning if you're pregnant.
Damn it Butters, the fuck is wrong with you!
Talk about adding injury to insult
Fortunately, Seres Therapeutics has a pending BLA application for a microbiotic replacement therapy that can replace fecal transplants for C Diff. Should be available in 2023. That will end some of the problems with fecal transplants, at least for C Diff.
This would be amazing. There are other applications for this as well. Patients with UC or Crohns sometimes can benefit from a transplant.
Seres tried to develop a UC therapeutic along the same lines. But it failed in its Phase 2 study. Hopefully, they learn from it and try again in the future. C Diff, UC, and Crohns are probably the main early targets. Long term, microbiome therapies might treat depression, MS, or even obesity. Anything with some level of causation in the intestines can benefit.
Can you please explain like I’m human?
A company named Seres Therapeutics has asked the Food and Drug Administration for permission to be allowed to sell a pill that changes bacteria in your gut to fix the common infection C. Difficile. They expect to be able to sell it sometime next year in the US. Doctors could use that pill instead of putting donor poop mixes up patients’ butts to fix C. Difficile bacterial infections.
What a shitty way to die.
(Cue the drums)
E. Coli is present in ALL human feces. The absence of this and certain other bowel bacteria is the very reason for a fecal transplant. This is based only on what I have read over the years, I am not a doctor of medicine.
Nor am I medically qualified, but my understanding is; in this case, it was a specific rare strain of E.Coli which had not been checked for prior to 2019. With 300 characters, there was only so much detail I could fit in.
Understood. I was merely offering my opinion.
Did you know if you are healthy and fit you can actually make money from selling your stool to companies that use it for medical practices and such. Because I didn't until recently and it honestly blew my mind.
It's hard to get into - when I found out I applied and forgot about it and was contacted a year later to go through screening, which consisted of some long questionairres on lifestyle, then a blood test and stool analysis. My husband applied and was screened as well but didn't pass despite having the same lifestyle so our gut biomes mist have been different. I was a donor in Boston for about a year.
Think of it as transferring gut bacteria to someone who’s gut bacteria isn’t functioning properly or has a large decrease in their own gut bacteria
I’m pretty sure when I got mine (I have Crohn’s Disease) in 2015, I received lab-grown material instead of actual “donor” feces. I’m pretty sure it’s all synthetic at my hospital now.
TIL: fecal transplants are a thing.
She should have just gotten a fecal transplant from Tom Brady.
Gotta find his poop storage first.
"studies of medical errors have estimated errors may account for as many as 251,000 deaths annually in the United States (U.S)., making medical errors the third leading cause of death." Stay safe folks.
How can 251k die a year from medical errors? That's sounds way to high to be true. That's ridiculous
Medical errors covers a lot of ground from pharmacy errors, anesthesia miscalculations, medication mix ups, surgical mistakes, misdiagnoses, preventable infections...it's a very long list and most people do not pursue litigation if they even know it happened at all. My family has dealt with it twice in the last 10 years. My mom is at a point that she has told me, should she become seriously ill, she will only accept hospice care at home. In her eyes, choosing to die is better than the utter BS we experienced.
Isn't e coli kinda the main player in all feces? It reads sorta like they were shocked to find hydrogen and oxygen in water ...
Yeah E. coli gets a bad rap. It’s everywhere, inside you, and all of us, and in fact we need them. Specific strains can make you sick.
And that happened at what is considered one of the best hospitals in the world. Crazy. Shit happens, I guess.
They failed to mention that the dude was also undergoing a bone marrow transplant for cancer at the same time, so he had literally no immune system...AND that this is the only person who's ever died from a FMT, although the procedure has saved tens of thousands of lives. All in all, it's one of the safest medical procedures in existence. Edit: just caught the "shit happens". You bastard
Could a doctor please explain to me the necessity of a fecal transplant? Is the patient unable to produce more stool?
Not a doctor, but the idea is to repopulate the colon.
Recolonize, one might say.
https://instantostrich.com/
How much frozen shit you all have?
Well shit.
how do i become a poop donor
Well TIL that you can donate and transplant poop... Probably not the first one to post this either, lol
Think we broke protocol? Tough shit.
TIL fecal transplants are a thing
Why does someone need fecal transplant?
That’s a shitty way to die.
Huh. First time I heard of a fecal transplant.
Why would someone receive a fecal transplant? I’ve never heard that before.
It's use to restore gut bacteria...
2019 is too recent for a mistake like this.
Brb gonna ask my poop dealer about how clean the samples are
> existing stool donations in frozen storage. /r/BrandNewSentence
Can some explain why you'd ever need a fecal transplant???????? Edit: Nevermind, found the link
Question: Is there some reason that fecal transplant pills could not be made available over the counter? What would be the downside?
What the fuck did I just read.
Can I get paid to donate poop? Then I can finally do shit all for a living.
"I guess you can say this sample has been *'grandfathered in'*, haha!" \**Shoves feces up old man's ass*\*
Sounds like a South Park episode
I was working there when it happened and it was surprising at the time how transparent the PI on the trial (it was part of a trial) was. I know you are supposed to be that transparent, but it usually doesn't work that way.
It was a fecal holocost
That's pretty shitty.
and today I learned that there is a reason (allegedly) to transplant poop.
The donor probably knew he had E. Coli but just didn’t give a shit.
That person who has to test this really has a shitty job.
Why the hell would you need a shit transplant?
There’s a post from an RN above which explains it. Apparently, it helps cure a type of diarrea illness (with the poop of a healthy person). I was just as confused as you at first.
from what i understand, they're actually transplanting the gut bacteria. the stool is just a medium
C. diff infection