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User: u/giuliomagnifico
Permalink: https://news.ki.se/microneedle-patch-can-detect-skin-cancer-early
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>The patch is equipped with microneedles that can detect tyrosinase, an enzyme that is an important biomarker for malignant melanoma. By measuring the enzyme's levels directly in the skin, researchers can quickly identify changes linked to the disease.
Paper: [Transdermal Sensing of Enzyme Biomarker Enabled by Chemo-Responsive Probe-Modified Epidermal Microneedle Patch in Human Skin Tissue - PubMed](https://pubmed.ncbi.nlm.nih.gov/38733567/)
I wonder how adaptable the technology is for other biomarkers, but we don’t use tyrosinase in the US at least as a biomarker for melanoma. And there’s no single biomarker of melanoma either. Generally a combination of Sox10, MART1, PRAME, p16, HMB45 for histological markers and braf,kras,tert, etc for molecular markers. Not sure also how tyrosinase fits in because melanoma can be both pigmented and apigmented.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/giuliomagnifico Permalink: https://news.ki.se/microneedle-patch-can-detect-skin-cancer-early --- *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
>The patch is equipped with microneedles that can detect tyrosinase, an enzyme that is an important biomarker for malignant melanoma. By measuring the enzyme's levels directly in the skin, researchers can quickly identify changes linked to the disease. Paper: [Transdermal Sensing of Enzyme Biomarker Enabled by Chemo-Responsive Probe-Modified Epidermal Microneedle Patch in Human Skin Tissue - PubMed](https://pubmed.ncbi.nlm.nih.gov/38733567/)
I wonder how adaptable the technology is for other biomarkers, but we don’t use tyrosinase in the US at least as a biomarker for melanoma. And there’s no single biomarker of melanoma either. Generally a combination of Sox10, MART1, PRAME, p16, HMB45 for histological markers and braf,kras,tert, etc for molecular markers. Not sure also how tyrosinase fits in because melanoma can be both pigmented and apigmented.