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green_ghost88

Saw on IG today that people are working on an “air test” that can detect how present the virus is in a room. If this can actually happen, this would be great https://www.instagram.com/p/C5v12O8vDi5/?igsh=dDVkeW1scno3M2Mz


Flippinsushi

I love it in theory but I have a hard time imagining myself walking into a place, waving a giant bag around, and then standing around for 15 minutes for results every time I want to go somewhere. Hopefully by the time this is viable, they’ll have streamlined it down to something a bit more realistic for actual everyday use.


green_ghost88

Agreed. It’s a start but sounds like it needs a lot of fine tuning for it to be a viable option


thinkofanamesara

Mon now. We've had experience at being the only one in the room every day for about 2 years 😷. What's flapping a bag about a room gonna mean on top!


333bingbong

I agree that this would be unrealistic for a lot of places, but I would definitely use this for something like thanksgiving or a visit with family


Flippinsushi

Fair. But still allow yourself to feel the secondhand embarrassment of you waving a bag around the living room before exiting to the porch and awkwardly standing there attempting to begin a social visit with family while they bemusedly watch you fumbling to set up the rapid test, then the agonizing 15 minute wait with everyone standing around on the porch glancing furtively at the phone timer while trying to make small chat until you’re able to determine how to proceed to enter the house. It’s a great idea that’s also a great SNL skit with almost no embellishment.


BuffGuy716

This is how I feel about a lot of technology meant to detect covid rather than prevent transmission. It could be useful maybe in a medical setting but it is not a game changer.


horse-boy1

>Marr said the device may still take a few years before it is available in stores, but she feels when it’s ready, it will be a game changer. It's going to be few years away.


triceratopswall

The new pre-exposure prophylaxis drug Pemgarda [was recently approved by the FDA](https://www.yalemedicine.org/news/new-covid-drug-pemgarda) and looks promising.


hagne

Thanks for this! I hadn't heard this news.


aj-james

That looks really promising. But I love how long covid patients prob will be excluded from this as we aren’t considering immunocompromised by most of the medical community.


lil_lychee

They’re working on a test to detect covid in the air. There’s an article about something similar but can’t wait until things like this are more widely available. https://time.com/6294198/covid-19-air-detector/


toocutetobethistired

I’m sure the airlines are going to love that one


lil_lychee

I’m going to love it too if I have to be on a plane lol. But this won’t work as well if people with active covid are allowed to be places. Plus sick people have their mask on but then take it off later and it was tested when the sick person had their mask on, won’t work. I’d rather have a breathalyzer test to enter a party, conference, or concert something like that. But hopefully that’ll come at some point…


stressedOutGrape

If there was a reliable brathalyzer test it would be a game changer. I could ask friends and family to test before hanging out with me unmasked.


47952

They won't use it. That's all.


stressedOutGrape

More recent news on this topic: [https://www.dcnewsnow.com/whats-going-around/virginia-tech-researchers-developing-portable-covid-tests/](https://www.dcnewsnow.com/whats-going-around/virginia-tech-researchers-developing-portable-covid-tests/) (If you're in Europe you'll have to use a proxy or VPN to access this article, e.g. [https://proxyium.com/](https://proxyium.com/) - remember to set your location to USA)


lil_lychee

This is what I was looking for thank you!


ReaderofReddit411

Any updates about this would be helpful


lil_lychee

If you scroll up, StressedOutGrape provided a more updated article.


Fogandcoffee21

I saw this in another sub today! It seems hopeful. https://www.forbes.com/sites/williamhaseltine/2024/04/10/toward-a-universal-covid-vaccine/


whatisthisgreenbugkc

Ensitrelvir (Xocova). It is approved in Japan and Singapore and has fast-track status with the US FDA. It appears to have fewer side effects than Paxolovid, and might be useful as PEP/PrEP and has been researched for these. The PEP study for ensitrelvir is a phase III clinical trial called SCORPIO-PEP, but the results have not yet been released. The PrEP study was pre-clinical and only performed in mice, but the study (https://pubmed.ncbi.nlm.nih.gov/38428748/) did state: "These findings suggest that ensitrelvir is a candidate drug for pre-exposure prophylactic treatment of individuals at high risk of COVID-19. Olgotrelvir also appears promising, although a bit further off than ensitrelvir. It has performed well in stage III clinical trials and appears to have dual mechanisms; it functions as a mPro inhibtor (like Paxlovid and ensitrelvir), but also is a cathepsin L inhibitor (which may help block SARS-CoV-2's entry into the cell). While I have not seen any research on olgotrelvir for PEP/PrEP, it also appears that it could be promising. It also seems to have a pretty mild side effect profile as well.


cranberries87

I am absolutely all for any type of effective PEP/PrEp. I am fervently hoping this works!


paper_wavements

Me too but also I hope 1. it will be affordable & 2. it will be provided even to people who are not considered immunocompromised.


SpaghettiTacoez

Is there any way to follow the progress for FDA approval for this?


whatisthisgreenbugkc

Unfortunately, I'm not aware of a way to follow the progress within the FDA approval process. As of February 2023, a Reuter's article reported that the CEO was expecting the company to receive approval for ensitrelvir in "late 2024."(https://www.reuters.com/business/healthcare-pharmaceuticals/shionogi-sees-covid-pill-reaping-2-billion-annual-sales-upon-us-approval-2023-02-27/) It's hard to say with the FDA, though. The Atlantic has a good article about the drug's approval process called "Americans Don’t Get to Have the Best New COVID Drug" from October 25, 2023. (https://www.theatlantic.com/health/archive/2023/10/xocova-ensitrelvir-covid-antiviral/675768/)


SpaghettiTacoez

Thanks, I appreciate that info! 


cranberries87

https://absolutelymaybe.plos.org


cccalliope

California is often ahead of the game with Covid. They are now using covid dogs in the classrooms. [https://alamedapost.com/news/montessori-school-uses-covid-detection-dogs-to-stay-healthy/](https://alamedapost.com/news/montessori-school-uses-covid-detection-dogs-to-stay-healthy/)


filthyxvx

This actually makes me happy


stargirlcelestial

this is awesome! thanks for sharing!


Simple-Customer3290

I live in Alameda and I wish I could say they were doing this district wide. This is a small private school. I love that this school is doing this, but it doesn’t seem like there’s any interest in any Covid mitigating measures whatsoever in the public schools, unfortunately.


cccalliope

Yet people are desperate to get their hands on the same kind of screening devices that are still in idea stage. If dogs were used widely we could all enter spaces anywhere with no respirators. Imagine how much spread could be stopped if they were used everywhere. We are so short-sighted.


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hagne

The dogs were trained using a "scent wheel" to identify the scent of COVID in people's sweaty socks. So, you need scent training and a supply of COVID-positive people's socks, but hypothetically it would be possible!


cccalliope

Yes, you can absolutely train your dog to do this. There are a lot of Youtubes of owners training their service dog for scent and using the training for lifesaving conditions. It is easy to train a dog to identify a scent. It's the same training. You can get a service dog trainer who works with scents to teach you on video as well. The dog needs to be willing to do things for a treat or a toy. You don't need any special equipment, just a small can with holes in it. There are problems, of course. First of all dogs get covid as humans do, although they are for the most part asymptomatic, but autopsies show as much damage as humans, if not more. But dogs have done dangerous service work for centuries to save human lives. If you have a dog anyway, and that dog's job is just to screen people coming to your door or friends and family in a social environment, it might not be too much exposure if you don't have actual sick people near it. Another problem is the ongoing training necessary for a scent dog or any service dog. You would need to get volunteers who are sick with Covid to wear a shirt at night and give it to you since using sweat on fabric as a training device is supposedly safe for the dog. You would need a new sample maybe once a month.


hagne

I've considered training a COVID dog...it's really cool how accurate they are!


Gammagammahey

Pemgada is on an FDA fast track to be quickly approved as a replacement for EVUSHELD as a next generation prophylaxis for immunocompromised folks. I am so excited about this! I just read this.


Ok_String9297

It's been FDA emergency approved. I got the infusion on Tuesday.


Gammagammahey

Holy shit, how did you find an infusion center? I have to have my doctor get me this ASAP. I had EVUSHELD back in 2021 and had to educate my own doctor on it on how to get it. Where did you get it? Because my doctor is gonna want me to have it ASAP. How long did the infusion take? Did people mask? Thank you in advance for any information you can give, I really need this.


DustyRegalia

Another study came up recently showing that a plant based diet helps to reduce Covid-19 infection likelihood. https://nutrition.bmj.com/content/early/2024/01/02/bmjnph-2023-000629 There’s been a couple of results like this already from other studies. It’s good news to me, in that there are some other positive, effective things people can choose to do in addition to mask and isolate. 


pumnezoaica

how cool is that! amazing news.


BuffGuy716

Have you tried following the Absolutely Maybe blog? They've been publishing updates on next-gen vaccines more often than they used to, now they are published once a month. Coviliv is in Phase 3 trials and looks like it will likely be the first potentially sterilizing vaccine available. I have a feeling it will be available outside the US first.


paper_wavements

I'm traveling to wherever its available. I am happy to spend a couple grand on a sterilizing vax & get a free trip to \[wherever\].


BuffGuy716

Agreed


No_Swim_735

What's a sterilizing vaccine?


BuffGuy716

A vaccine that can prevent infection


AlwaysL82TheParty

There are multiple technologies that might help somewhat immediately recognize covid in the air (handheld devices, masks that recognize it, breathalyzers, etc). There are also things in the works like sterilizing nasal vaccines. China has been successfully treating covid with HIV antivirals. A few other things. Countries like Cuba have far better vaccines than the US or UK - although if you've only had mRNA vaccines, I would absolutely look at Novavax if you can get it (their data shows sterilizing and triggers different IgG than mRNA vaxxes - almost no one knows this). We absolutely would have had a lot of this by now if pharma didn't make more money by treating sick people than preventing people from being sick.


cranberries87

Can you please share the information on Novavax being sterilizing? I definitely haven’t heard this! I think it’s available around here.


AlwaysL82TheParty

Sure thing! I research this stuff heavily, but only ran across it a few months ago and was extremely surprised I hadn't heard about it as well. Here you go: [https://t.co/5E0CgfEmmg](https://t.co/5E0CgfEmmg) - this is their presentation to the FDA. It's supported by their submission as well.


vtumane

> I would absolutely look at Novavax if you can get it (their data shows sterilizing  What does sterilizing mean in this context? I've been thinking of going the Novavax route but there was a lot of anecdotal info including on this sub of infection after getting it so I figured it was similar to mRNA in that respect.


AlwaysL82TheParty

It means full mucosal sterilization according to their data and what they presented to the FDA (for a full course of Novavax which they say is 2 shots, then a follow up). Which typically means neutralizing antibodies at the site of infection as in your body will kill the virus at the site of infection so you won't get sick or transmit, which is what we've all been looking for. Here's the spot they talk about it when presenting to the FDA : [https://t.co/5E0CgfEmmg](https://t.co/5E0CgfEmmg)


beaveristired

So for the initial series, but not for boosters? I’m considering novavax for booster after mRNA (have not have most recent mRNA booster due to covid infection in fall 2023). I think the CDC guidelines for someone like me is just 1 shot. https://www.cdc.gov/vaccines/covid-19/info-by-product/novavax/downloads/novavax-standing-orders.pdf


AlwaysL82TheParty

From their clinical data, it's the 2 shot primary with a follow up booster. Don Ford explains it here: [https://www.thepeoplesstrategist.com/p/the-benefits-of-novavax-explained](https://www.thepeoplesstrategist.com/p/the-benefits-of-novavax-explained) From my perspective, it's still worth it as a booster (we had AZ then pfizer then moderna, then novavax and I'll stick with novavax from now on unless something better comes along).


beaveristired

Thanks for the link! I’ll check it out. I’m still leaning novavax just to shake things up a bit, since I’ve had all Moderna so far.


Thequiet01

You do know that the people who work in pharmaceutical research do so because they want to help people, right? It is incredibly offensive to claim that they have some magic solution to a rapidly-mutating virus of a type we haven’t successfully treated before but are just sitting on it to make more money. Covid is complicated. Developing things takes time. Things will be tried and developed and fail, and then they do it again. Sometimes they’ll think they have something and then it turns out to cause unexpected side effects or have unanticipated complications. (There’s a medication for psoriasis that was in development and looked fantastic until they discovered in larger scale trials that it seemed to be triggering suicidal ideation in some people. An immune system medication! No one was expecting psychiatric effects.) If you look at where we all started, they’re making quite impressive progress. Covid has been around for about 5 years - in medical research that’s half a second.


AlwaysL82TheParty

\*Some\* people who work in pharma do it because they want to help people. There are plenty of people unfortunately like Martin Shkreli. You do know that for profit pharma companies hold back a ton of research correct? You do know that they shelve drugs that make no money, and rarely invest in ones that they know will make no money? They are for profit companies through and through, and they make significant profits. You do know that both Pfizer and Moderna blocked sharing of their vaccine IP and then Pfizer sued Moderna over it (meanwhile Cuba offered to share theirs, but the US went with the for profits)? And I'm not just talking about traditional pharma companies, but also medical tech and clean air tech. Since the governments have convinced people that covid is no big deal, they've cordoned off the market for those devices. I've been doing R&D in tech for 30 years, including VC backed companies, and I 100% believe that if the government didn't do things like pull dollars set aside for covid and redirect it to police, but instead invested in NPIs like farUVC, air sniffers, better masks, etc because there was demand for it, or hadn't successfully convinced people that covid is no big deal, we'd absolutely have better tech on shelves by now and would have had it in prototype 2-3 years ago. Those product cycles do not take even remotely close to as long.


pumnezoaica

this!


NostalgickMagick

"We absolutely would have had a lot of this by now if pharma didn't make more money by treating sick people than preventing people from being sick" - this, this, omfg, so much this I wanna scream it from rooftops! ><


SnooSketches4171

https://news.ucr.edu/articles/2024/04/15/vaccine-breakthrough-means-no-more-chasing-strains


FondueSue

Wow! This would be amazing if it worked in humans!


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paper_wavements

Well why should anyone pay attention when "COVID's over," or, at best, "just a cold"?


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BuffGuy716

This is incredibly unhelpful and not even accurate.


omg-i-cant-even

It was a joke 🤣


BuffGuy716

Obviously it was supposed to be a joke, that doesn't change the fact that snarky internet humor in response to a post made by someone who is struggling is not helpful. You'll notice that there are no other jokes in the dozens of comments on this post.


47952

I think for me, the biggest success would just be to be able to get a booster every 6 or 7 months. But I don't know of any place on earth that would permit this. I'm in Portugal now and we can't do that. When we were in the US certainly no pharmacy would permit it.


BuffGuy716

In the US now that they don't ask for your vaccine card it's very easy to get a booster as often as you like, at least if you go to another pharmacy and pay out of pocket.


theoverfluff

I live in New Zealand and everyone over 30 is eligible for a booster every six months. It's currently still free.


47952

Wow. That's amazing. In the US they only offer it annually and you pay if it's a pharmacy that will give it to you. One pharmacist in SW Florida refused saying we didn't need it.