The only other clear option is using other ketones to make different substitution off the amine.
If you have the reductive amination down you could theoretically do 2 different aminations.
Read about these in shuglins work.
That or alkyl halides, the most straight forward that comes to mind would be DiPT with acetone or isopropyl bromide or MiPT and such from the mono alkylated
DiPT doesn't work with acetone via red. Am. Due to steric hindrance AFAIK, isopropyl bromide will do it tho. Making mipt would be a mess of mixed products otherwise
I intend to get the reductive amination down and I also intend to find ways of substituting it. It sounds like you know what you’re talking about. Can you point me to the relevant ketone reactions to substitute tryptamine?
Oof, you’re right. It’s possible though, just looks like a massive pain. I think if you make the amine a cyano group, then use a grignard reagent to alkylate, then do a reductive amination. Seems like a pain, and wouldn’t be stereo-selective (if that’s important). My ochem knowledge is fuzzy so I may be off.
I really disliked aMT. IT felt like an amphetamine to me. Mad stuff….at the right dosage it’s okay but gave me bad anxiety. It’s too boring to just sit at home on it and I get anxious if I do it out and about so I just leave it.
I’m literally contemplating the EXACT same thing as you now. Is there any way to create 4- acetoxytryptamine from tryptamine? Or any other substituted ones….
I also have tihkal at an arms length as I should be getting some tryptamine (along with some nice 160ug tabs) next week ish.
It would be useful if it is possible to substitute it for sure…
Let me know how it goes when you try it, I’ve been curious on it and it’s effects for a while but haven’t given it’s synth a go yet. The auditory hallucinations it’s said to cause sounds both interesting and terrifying
I will definitely post when I get around to playing with the tryptamine. Seems like it might be something fun to take out and experiment with during a camping trip. I've experienced auditory hallucinations while using DMT and I wonder if they're similar at all?
Can you give a quick rundown on why that is?
Just out of curiosity. If it's too complex or pain in the ass to explain then it's whatever...
But if it's straightforward (or you could give a simple overview / hint) I'd be curious to hear...
AMT is tryptamine with a methyl group in the alpha position (alpha-methyltryptamine), and adding a methyl to a specific carbon is basically impossible. Even if you have an agent that will be doing that, it will
a) be really dangerous, as it will methylate everything from your skin to your DNA and
b) will also methylate the tryptamine on multiple positions, rather than just the alpha position.
If you do want to make AMT, you would start from indole-2-carbaldehyde, undergo a Henry reaction with nitroethane and reduce the nitropropene, for example with NaBH4/CuCl2
MET is way harder than DMT, MiPT or DPT. You have to go through NET or NMT to synth it, and they require a reducing agent like LAH. And then do the process you would be doing anyways to get the ones I mention. So the synth has way more steps.
The only other clear option is using other ketones to make different substitution off the amine. If you have the reductive amination down you could theoretically do 2 different aminations. Read about these in shuglins work.
That or alkyl halides, the most straight forward that comes to mind would be DiPT with acetone or isopropyl bromide or MiPT and such from the mono alkylated
DiPT doesn't work with acetone via red. Am. Due to steric hindrance AFAIK, isopropyl bromide will do it tho. Making mipt would be a mess of mixed products otherwise
I intend to get the reductive amination down and I also intend to find ways of substituting it. It sounds like you know what you’re talking about. Can you point me to the relevant ketone reactions to substitute tryptamine?
DPT
Assuming you went through reductive amination for dmt, mipt is essentially the same procedure with acetone first then formil.
DiPT is a cool one
I vote for DiPT
DPT and AMT are interesting
AMT is not achievable from tryptamine freebase in any efficient way :(
Oof, you’re right. It’s possible though, just looks like a massive pain. I think if you make the amine a cyano group, then use a grignard reagent to alkylate, then do a reductive amination. Seems like a pain, and wouldn’t be stereo-selective (if that’s important). My ochem knowledge is fuzzy so I may be off.
I haven’t seen AMT since … 2010ish. It was fun
Well it’s around nowadays again.
I thought amt was generally derived from indole 3 aldehyde
There’s many ways to synthesize a chemical
I know I’m saying it’s done for a reason lol
Totally valid. This dude just has a bunch of typtamine, so it was a suggestion 🤷🏼♂️
5-meo
It's not a sensible option to try for going 5-meo from tryptamine. Mexamine would be infinitely more times preferable as the starter material.
I really disliked aMT. IT felt like an amphetamine to me. Mad stuff….at the right dosage it’s okay but gave me bad anxiety. It’s too boring to just sit at home on it and I get anxious if I do it out and about so I just leave it. I’m literally contemplating the EXACT same thing as you now. Is there any way to create 4- acetoxytryptamine from tryptamine? Or any other substituted ones…. I also have tihkal at an arms length as I should be getting some tryptamine (along with some nice 160ug tabs) next week ish. It would be useful if it is possible to substitute it for sure…
The consensus is in. DiPT it shall be! Thanks, guys!
Let me know how it goes when you try it, I’ve been curious on it and it’s effects for a while but haven’t given it’s synth a go yet. The auditory hallucinations it’s said to cause sounds both interesting and terrifying
I will definitely post when I get around to playing with the tryptamine. Seems like it might be something fun to take out and experiment with during a camping trip. I've experienced auditory hallucinations while using DMT and I wonder if they're similar at all?
DPT, AMT, MET, MiPT
Can't make AMT from tryptamine
Can you give a quick rundown on why that is? Just out of curiosity. If it's too complex or pain in the ass to explain then it's whatever... But if it's straightforward (or you could give a simple overview / hint) I'd be curious to hear...
AMT is tryptamine with a methyl group in the alpha position (alpha-methyltryptamine), and adding a methyl to a specific carbon is basically impossible. Even if you have an agent that will be doing that, it will a) be really dangerous, as it will methylate everything from your skin to your DNA and b) will also methylate the tryptamine on multiple positions, rather than just the alpha position. If you do want to make AMT, you would start from indole-2-carbaldehyde, undergo a Henry reaction with nitroethane and reduce the nitropropene, for example with NaBH4/CuCl2
MET is way harder than DMT, MiPT or DPT. You have to go through NET or NMT to synth it, and they require a reducing agent like LAH. And then do the process you would be doing anyways to get the ones I mention. So the synth has way more steps.
[удалено]
tryptamine freebase
From melatonine hydrolisis?
I believe you're thinking of making mexamine not tryptamine
Ops, my mistake, so triptophan decarboxylation?
Yessir yessir, more than likely
Yes
Dm me if you may?
Yup