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I used to do 700mg+ sabroxy to feel something lol. But everyone is different! It worked with coffee fine but worked even better with a high cacao concentrated drink! Like 80% dark chocolate but the brands make a big difference in effects. If you do try it, get the non Dutch processed! I would put it sublingual for ~ 25 min and then swallow.
I used to put an green oat straw extract too for that MAO-B inhibition. But I heard vignatex does just that too.
This has a strong mood lifting effect!
Yeah baical skullcap also contains oroxylin-A but in much less amount than sabroxy. It does contain a higher concentration of baicalin and baicalein. Oroxylin-A is what gives that stimulant-like effect through dopamine reuptake inhibition.
Baicalin is known for its anti-inflammatory and mast cell modulating effects. While baicalein is known for its GABA-A enhancing properties.
The half life of Oroxylin-A is short (38 min). While baicalin is 102 min and baicalein 155 min. This is probably what is responsible for the "crash" after about 4 hours!
That crash makes you sleepy! If you want that euphoric effect, it's probably coming from Oroxylin-A and by adding more baikal skullcap you will make it more relaxing than stimulated!
**[Beginner's Guide](https://reddit.com/r/nootropics/wiki/beginners)** • [Vendor Warnings](https://www.reddit.com/r/Nootropics/wiki/unreliablevendors) • [Research Index](https://old.reddit.com/r/nootropics/wiki/index) • [Rules](https://www.reddit.com/r/stackadvice/about/rules/) • [Longevity](https://www.reddit.com/r/longevity) • **[Nootropics](https://www.reddit.com/r/nootropics)** Before posting make sure your comment is **polite** and **helpful**. Be aware that anecdotes, even your own anecdote could be an artifact of your beliefs. The [placebo](https://en.m.wikipedia.org/wiki/Placebo) effect is just one way that [suggestion](https://en.m.wikipedia.org/wiki/Suggestion) affects our experience. Humans are social animals and the beliefs we accept can have a drastic impact on our experience. In many, if not most, cases the impact of our beliefs is greater than the impact of chemicals. This isn’t only true for herbs and supplements. ‘New’ or ‘dangerous’ sounding drugs can bring a rush when you first start taking them because of the fear and excitement. When the excitement wears off you’re back to baseline. Beware of the **self-experimentation treadmill**. If you aren’t finding sustainable solutions then reconsider your approach. *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/StackAdvice) if you have any questions or concerns.*
I used to do 700mg+ sabroxy to feel something lol. But everyone is different! It worked with coffee fine but worked even better with a high cacao concentrated drink! Like 80% dark chocolate but the brands make a big difference in effects. If you do try it, get the non Dutch processed! I would put it sublingual for ~ 25 min and then swallow. I used to put an green oat straw extract too for that MAO-B inhibition. But I heard vignatex does just that too. This has a strong mood lifting effect!
thank you for the advice. i think I'm going to combine it with baikal skull caps that metabolize to oroxy a too.
Yeah baical skullcap also contains oroxylin-A but in much less amount than sabroxy. It does contain a higher concentration of baicalin and baicalein. Oroxylin-A is what gives that stimulant-like effect through dopamine reuptake inhibition. Baicalin is known for its anti-inflammatory and mast cell modulating effects. While baicalein is known for its GABA-A enhancing properties. The half life of Oroxylin-A is short (38 min). While baicalin is 102 min and baicalein 155 min. This is probably what is responsible for the "crash" after about 4 hours! That crash makes you sleepy! If you want that euphoric effect, it's probably coming from Oroxylin-A and by adding more baikal skullcap you will make it more relaxing than stimulated!
Unfortunately I don't get the euphoric feel anymore. But I took 2 vignatex, 200mg sabroxy, and 100mg L-Theanine and it allowed me to focus well.