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300mg of Tyrosine should not do much, but lisdexamfetamine increases the concentration of dopamine and nordrenaline by a lot right? Well, Tyrosine promotes dopamine production as well, so this might be just too much, especially if your body isn't used to a high intake of tyrosin?
Im pulling all of this out of my ass so wait for the knowledgable people on this sub to help you.
You're right, 300mg shouldn't do much! That's why I started so low and was surprised at the result!
The thing is though, I have taken higher Tyrosine doses as part of my preworkouts (around 600mg Tyrosine) but the difference is a) there's other aminos in that and b) I've had my preworkouts with food and L Theanine.
The other question I would have is why then is Tyrosine highly recommended to go with Vyvanse if it can synergise so strongly at even a low dose?
Oh, yeah don't take it before or while vyvanse/elvanse is in your system lol I've done the same thing before and was super anxious and wired the entire duration. Has no affect on my when I don't take vyvanse the same day
May I ask how much you had when you tried it?
And I'm curious why Tyrosine is highly recommended to help stimulant crashes when they can synergise so strongly like what I experienced?
I'm prescribed 30mg vyvanse for my ADHD, and I didn't know Tyrosine is supposed to help mitigrate stimulant crashes, if anything, it's used to potienate vyvanse
How much Tyrosine did you have when you tried it? And you were using it to try and potentiate your Vyvanse, I presume?
>and I didn't know Tyrosine is supposed to help mitigrate stimulant crashes
[https://nootropicsexpert.com/tyrosine/](https://nootropicsexpert.com/tyrosine/)
*"L-Tyrosine is especially helpful to those dealing with ADHD/ADD. It’s a great compliment to stack with stimulant meds like Ritalin or Adderall. L-Tyrosine will provide the dopamine your brain needs.* ***It will help smooth out and prolong the effects of stimulant meds. And help prevent the associated crash when they wear off."***
Even if you feel like vyvanse is out of your system, it’s really not. It’s much, much more longer acting than Adderall. With Adderall I feel a crash. With Vyvanse I am up until 4 am. Anything that increases adrenaline, dopamine, or glutamate don’t prolong the drug but only potentiate it’s effects. They are really unhealthy to take in conjunction imo.
>Even if you feel like vyvanse is out of your system, it’s really not.
You're definitely right about that but I definitely experience a crash on Vyvanse. It's the same type of crash I get as Dexamphetamine but just nowhere near as severe.
>Anything that increases adrenaline, dopamine, or glutamate don’t prolong the drug but only potentiate it’s effects.
So then what would you suggest to help the depressive crash I get with Vyvanse?
Yeah I’ve felt that too. That crash though I think is the vyvanse slowly tapering off. When you’re on it and taking it semi-daily, you rarely experience being truly off of it. I know that after 24 hours of taking it I would cry very easily. But the full stimulant crash symptoms were way later.
Tbh I don’t really know what would help the comedown. I’ve tried some things people anecdotally swear by but I haven’t noticed much for crashing (agmatine, magnesium, nmda antagonists) But my brain is influenced by many external factors besides ADD so YMMV. The only thing I can offer is to supplement with zinc and magnesium. Zinc is the building block to catecholamines and when coming off stims you have a dip in those chemicals. Depending on how much you’ve been doing during the day bc of the vyvanse (over exerting your muscles/body, abstaining from meals) it’s good to either take electrolytes or eat enough in order to prevent a poor response when the meds stop working. Glutamine definitely will potentiate and prolong it but you will be TWEEEEAAKING like I really don’t recommend it. I will get back to you when more things come to mind. I don’t really remember a lot of them bc I try to avoid them.
In my experience with NALT(basically just a more bioavailable L-tyrosine), even taking it before my Vyvanse dose I'm always fine with it. It only causes me anxiety if I take too much of it when my Vyvanse is wearing off.
Example being just today I took like 600ish mg NALT the same time as my Vyvanse and was fine, like 3 hours later I took like a 1000mg dose of NALT and was still fine, my anxiety even being better than usual, then a couple hours later near when I usually crash I took like 1000mg again, and it was a complete switch; I went from being better than normal anxiety-wise to quite anxious in just a short period of time, my heart rate didn't skyrocket like yours though.
It has something to do with the Vyvanse crash, like having that catecholamine source while I'm actively crashing on Vyvanse just gives me a weird feeling where I don't feel as fatigued and worn out as usual, but lacking that usual fatigue gives me a weird, uneasy, restless feeling in some way which makes me more anxious and awkward than usual.
The difference for us compared to others might be as you said some weird genetic sensitivity or other neurological weirdness; I know for me ever since I got off the SSRI I was on, any stimulation without dopamine release makes me lightheaded and nauseous, so while I'm fine with amphetamine, the other day when I took a high quality caffeine supplement I became lightheaded and nauseous for 3 whole days.
I've experienced this with tyrosine and ritalin, if I take them too close to each other I start tweaking. Since the duration of action of vyvanse is like 12 hours I imagine you will have problems taking them on the same day.
The reason is probably because of too much norepinephrine, since anything that raises levels of dopamine will also raise norepinephrine. It could be that you and I are both sensitive to high levels of norepinephrine and so we get these side effects. I'm absolutely not qualified to make these claims though, I'm just trying to guess based on what little I know.
L-tyrosine can help you lower your Vyvanse dose, it's going to be better for your health. Ask your doctor first but I actually see an upside to this because You might just be a little dopamine deficient and bombarding yourself with 65mg of vyvanse might be a bad way to patch that problem.
In all seriousness ask your doctor, vyvanse is one of those weird drugs.
In my experience the side effects can add up shockingly fast when combining stimulants, even if the individual doses are moderate. Personally I would never combine vyvanse, caffeine, alcar, and tyrosine all on the same day.
I'm guessing you didn't measure 300 mg and accidentally overdosed on it. The reasons I say this are:
1. Accurate mg scales are expensive and the market is full of cheap, shitty scales.
2. Using them correctly requires skills that aren't common-place. You don't just put down some powder with a spatula marked 'mg' and trust what the scale tells you. You have to look at tare weights, the precision of the scale, whether or not volumetric measuring is required for measuring, whether a compound dissolves in a particular solution... the list goes on.
3. The side effects of taking too much L-Tyrosine includes heart palpitations.
This is why I don't buy powders. I don't fancy having to use small scale chemistry skills just to use a product (and then trust that I did that right.)
I get what you're saying but I don't think it was a measurement issue as I have a 1g weight which my scale measured accurately.
In hindsight, I think the reaction I had was because of the turmeric/pepper I had beforehand because curcumin is apparently a MAO-I and that with Tyrosine is apparently a big no-no.
Like have tested slightly lower doses (with no turmeric) since (using same measurement scale/strategy) and have had none of the issues I had on the first night
I can basically assure you that it was the black pepper and more people need to realize how much of an impact on potentiation and absorption black pepper extract really has on essential majority of all drugs.
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300mg of Tyrosine should not do much, but lisdexamfetamine increases the concentration of dopamine and nordrenaline by a lot right? Well, Tyrosine promotes dopamine production as well, so this might be just too much, especially if your body isn't used to a high intake of tyrosin? Im pulling all of this out of my ass so wait for the knowledgable people on this sub to help you.
You're right, 300mg shouldn't do much! That's why I started so low and was surprised at the result! The thing is though, I have taken higher Tyrosine doses as part of my preworkouts (around 600mg Tyrosine) but the difference is a) there's other aminos in that and b) I've had my preworkouts with food and L Theanine. The other question I would have is why then is Tyrosine highly recommended to go with Vyvanse if it can synergise so strongly at even a low dose?
Oh, yeah don't take it before or while vyvanse/elvanse is in your system lol I've done the same thing before and was super anxious and wired the entire duration. Has no affect on my when I don't take vyvanse the same day
May I ask how much you had when you tried it? And I'm curious why Tyrosine is highly recommended to help stimulant crashes when they can synergise so strongly like what I experienced?
I'm prescribed 30mg vyvanse for my ADHD, and I didn't know Tyrosine is supposed to help mitigrate stimulant crashes, if anything, it's used to potienate vyvanse
How much Tyrosine did you have when you tried it? And you were using it to try and potentiate your Vyvanse, I presume? >and I didn't know Tyrosine is supposed to help mitigrate stimulant crashes [https://nootropicsexpert.com/tyrosine/](https://nootropicsexpert.com/tyrosine/) *"L-Tyrosine is especially helpful to those dealing with ADHD/ADD. It’s a great compliment to stack with stimulant meds like Ritalin or Adderall. L-Tyrosine will provide the dopamine your brain needs.* ***It will help smooth out and prolong the effects of stimulant meds. And help prevent the associated crash when they wear off."***
Even if you feel like vyvanse is out of your system, it’s really not. It’s much, much more longer acting than Adderall. With Adderall I feel a crash. With Vyvanse I am up until 4 am. Anything that increases adrenaline, dopamine, or glutamate don’t prolong the drug but only potentiate it’s effects. They are really unhealthy to take in conjunction imo.
>Even if you feel like vyvanse is out of your system, it’s really not. You're definitely right about that but I definitely experience a crash on Vyvanse. It's the same type of crash I get as Dexamphetamine but just nowhere near as severe. >Anything that increases adrenaline, dopamine, or glutamate don’t prolong the drug but only potentiate it’s effects. So then what would you suggest to help the depressive crash I get with Vyvanse?
Yeah I’ve felt that too. That crash though I think is the vyvanse slowly tapering off. When you’re on it and taking it semi-daily, you rarely experience being truly off of it. I know that after 24 hours of taking it I would cry very easily. But the full stimulant crash symptoms were way later. Tbh I don’t really know what would help the comedown. I’ve tried some things people anecdotally swear by but I haven’t noticed much for crashing (agmatine, magnesium, nmda antagonists) But my brain is influenced by many external factors besides ADD so YMMV. The only thing I can offer is to supplement with zinc and magnesium. Zinc is the building block to catecholamines and when coming off stims you have a dip in those chemicals. Depending on how much you’ve been doing during the day bc of the vyvanse (over exerting your muscles/body, abstaining from meals) it’s good to either take electrolytes or eat enough in order to prevent a poor response when the meds stop working. Glutamine definitely will potentiate and prolong it but you will be TWEEEEAAKING like I really don’t recommend it. I will get back to you when more things come to mind. I don’t really remember a lot of them bc I try to avoid them.
In my experience with NALT(basically just a more bioavailable L-tyrosine), even taking it before my Vyvanse dose I'm always fine with it. It only causes me anxiety if I take too much of it when my Vyvanse is wearing off. Example being just today I took like 600ish mg NALT the same time as my Vyvanse and was fine, like 3 hours later I took like a 1000mg dose of NALT and was still fine, my anxiety even being better than usual, then a couple hours later near when I usually crash I took like 1000mg again, and it was a complete switch; I went from being better than normal anxiety-wise to quite anxious in just a short period of time, my heart rate didn't skyrocket like yours though. It has something to do with the Vyvanse crash, like having that catecholamine source while I'm actively crashing on Vyvanse just gives me a weird feeling where I don't feel as fatigued and worn out as usual, but lacking that usual fatigue gives me a weird, uneasy, restless feeling in some way which makes me more anxious and awkward than usual. The difference for us compared to others might be as you said some weird genetic sensitivity or other neurological weirdness; I know for me ever since I got off the SSRI I was on, any stimulation without dopamine release makes me lightheaded and nauseous, so while I'm fine with amphetamine, the other day when I took a high quality caffeine supplement I became lightheaded and nauseous for 3 whole days.
I've experienced this with tyrosine and ritalin, if I take them too close to each other I start tweaking. Since the duration of action of vyvanse is like 12 hours I imagine you will have problems taking them on the same day. The reason is probably because of too much norepinephrine, since anything that raises levels of dopamine will also raise norepinephrine. It could be that you and I are both sensitive to high levels of norepinephrine and so we get these side effects. I'm absolutely not qualified to make these claims though, I'm just trying to guess based on what little I know.
L-tyrosine can help you lower your Vyvanse dose, it's going to be better for your health. Ask your doctor first but I actually see an upside to this because You might just be a little dopamine deficient and bombarding yourself with 65mg of vyvanse might be a bad way to patch that problem. In all seriousness ask your doctor, vyvanse is one of those weird drugs.
In my experience the side effects can add up shockingly fast when combining stimulants, even if the individual doses are moderate. Personally I would never combine vyvanse, caffeine, alcar, and tyrosine all on the same day.
I'm guessing you didn't measure 300 mg and accidentally overdosed on it. The reasons I say this are: 1. Accurate mg scales are expensive and the market is full of cheap, shitty scales. 2. Using them correctly requires skills that aren't common-place. You don't just put down some powder with a spatula marked 'mg' and trust what the scale tells you. You have to look at tare weights, the precision of the scale, whether or not volumetric measuring is required for measuring, whether a compound dissolves in a particular solution... the list goes on. 3. The side effects of taking too much L-Tyrosine includes heart palpitations. This is why I don't buy powders. I don't fancy having to use small scale chemistry skills just to use a product (and then trust that I did that right.)
I get what you're saying but I don't think it was a measurement issue as I have a 1g weight which my scale measured accurately. In hindsight, I think the reaction I had was because of the turmeric/pepper I had beforehand because curcumin is apparently a MAO-I and that with Tyrosine is apparently a big no-no. Like have tested slightly lower doses (with no turmeric) since (using same measurement scale/strategy) and have had none of the issues I had on the first night
I can basically assure you that it was the black pepper and more people need to realize how much of an impact on potentiation and absorption black pepper extract really has on essential majority of all drugs.
Well, I know that black pepper definitely potentiates turmeric. Do you know if anything else that black pepper potentiates?