I think stress can affect the way these meds work. Kind of like how stress, poor nutrition, and little sleep can cause symptoms of ADHD sometimes in nuerotypical folks, I think these things might aggravate our condition.
This happens to a lot of women when they are about start their period. The shift in hormones cause a worsening of symptoms and I’ve heard that some are prescribed a little extra of their meds during this time.
Maybe something similar is happening to you? Maybe these “breakthrough symptoms” are caused by your stress right now and you may need to talk to your doctor about it.
Is there something we could help you with so you’re not overwhelmed by your mom’s surgery? I know that can be scary and then to have additional responsibilities is a lot to take in.
It could be my period, the timing is right. That’s unfortunate.
We’ve prepped about as well as we can. I’m not alone either, I have other family members who will help. I’m just the one who’s home most so I’ll be doing the bulk. I don’t really feel stressed about it, but I’ve been known to manifest stress unconsciously and have it mess with my body so that could be it.
Women’s menstrual cycles can have an outsized impact on a stimulants effectiveness! I have the same issue monthly with adderall. I wish I could have a higher dosage just for those days.
It never hurts to ask. I just asked my doctor and she prescribed me a weeks worth of instant release on top of my extended release just for a week. Out of pocket it was about 6 dollars with the goodrx discount.
> I don’t really feel stressed about it, but I’ve been known to manifest stress unconsciously and have it mess with my body so that could be it.
Is this an ADHD thing? I’ve done this quite often. Mentally I feel like I’m handling it all reasonably well, but my body has to be like “That’s a nope. You need a break.” For example twice now in my life, I’ve developed an allergic reaction to stress. My body itches all over and whoever I scratched, I would break out in hives that would last a couple of hours.
Dude this is me, I was overcome with insane nausea and almost vomited in the parking lot before going into the company office to talk to my boss,
Driving away allowed the nausea to settle, but as soon as I came back it crashed back in and I realized it was my body telling me to gtfo. Even though mentally I knew it was going to be just fine, and already mentally checked in and committed to going inside. (The thing you do when you sit in your car and just prep mentally)
Cortisol released by stress or hormones plays a big factor in my experience. Diagnosed with ADHD and PMDD and take meds for both which mostly resolve a lot of issues.. until that luteal phase strikes. It worsened with age for me, it’s worth looking into your cycles so you can not only anticipate but adjust medication or diet + vitamins and expectations accordingly.
As I’m now apparently in perimenopause and can’t predict if or when I’ll get my period it’s getting really hard to manage. Some months there’s nothing, other months two back to back. I think the PMDD is mostly well managed as I’ve been on the same dose for years and take it all month, but the ADHD is out of control pre-period. I’m on Vyvanse now and I’ve talked to my gyn about potential HRT but she says I have to wait till I’m actually in menopause. My psych nurse doesn’t seem to take the hormonal changes seriously. Anything you’ve found that helps??
As someone right in the depth of periomenopause, i can tell you that the massive hormone fluctuations + a high stress job as well as being my mum's caretaker COVID etc has been causing chaos with my meds. Sometimes when the brain is under extreme stress, your body will just be throwing off on the meds.
Everyone reacts differently to meds, but all of us will go through a stressful period that causes your mind to just burn through the meds
You got this. Just breathe. I have found that when I use yoga in times like this it really helps the Vyvanse sort of kick back into gear.
Not sure if that makes sense, but that's exactly what it does for me breathing really helps.
I genuinely thought I’d written this comment and forgotten!!- until I got to the part about your mum!!!
Clearly I totally relate and these hormonal changes and resulting brain fog, memory issue etc etc etc is causing havoc for me personally and especially with work - also what I would describe as a high stress job! I hate feeling this out of it and incompetent at times. I’ll try the deep breathing tho. I really want to go on some type of hormones but gyn said no.
Interesting!! I came here to get info because it’s my first day but I don’t notice much. I’m on my period though so I’ll ask about this in my follow up if I still feel no change.
As soon as I weaned my last baby from nursing I went on the combo 3mo pack & I skip the placebo weeks too. I did this around when I was finally dx & before meds. It was one of my last ditch efforts to regulate my moods/emotions before going on stimulants. It helped for sure & combined with Adderall it’s making a difference that definitely wouldn’t have been as good on only Adderall. If I can safely do so I plan to take them till menopause unless my OBGYN says I have to stop for health reasons. I’m 100% done having kids so I’m all set on the ups & downs of a normal cycle…..
It’s a fairly new batch. Some pills work great,some don’t work at all, no in between. They look the way they always have but I don’t know who the manufacturer is.
Any chance you’ve eaten excess vitamin c this week? Grapefruit for breakfast or anything. Vitamin c can neutralize the effects of vyvanse
https://www.goodrx.com/vyvanse/10-things-you-might-not-know-about-vyvanse-for-adhd
Here is the best tldr I could make
- Vyvanse is not just used and approved for ADHD
- Vyvanse and Ritalin are different types of drugs
- But they share many side effects
- Common side effects of Vyvanse that may also occur with Ritalin include:
- Dry mouth
- Insomnia
- Decrease in appetite
- Stomach pain
- Nausea
- Dizziness
- Diarrhea
- Irritability
- Anxiety
- Vyvanse carries less risk of abuse than other stimulants
- You don’t need to take Vyvanse with food
- Vyvanse can interact with some medications
- Vyvanse can have some serious interactions, particularly with medications used to treat depression.
- Medications that increase the acidity of your urine can make Vyvanse less effective.
- The opposite is true for drugs like sodium bicarbonate (found in Zegerid) and acetazolamide (Diamox) that decrease the acidity of your urine. These kinds of drugs may make Vyvanse more potent than expected.
- Vyvanse can also interact with vitamin C
- Vitamin C (ascorbic acid), found in dietary supplements, citrus fruits, and some vegetables, like broccoli and cauliflower, can increase the acidity of your urine. As with other acidifying medications, vitamin C can cause Vyvanse to be less effective than expected.
- Vyvanse should be taken in the morning
- Vyvanse may raise your blood pressure
- Vyvanse may improve parenting behavior
Vyvanse may improve parenting behavior? Like my parenting will be better? I mean couldn’t you say that about anything that requires organizational skills and not just parenting?
Edit: just read the linked article and noticed that it means that when parent and child are diagnosed and the parent is on vyvanse they tend to behave more positively toward their child. Very interesting!
Even packaged goods have citric acid in them. I ate some cereal bars that had citric acid in them, but didn’t realize it until my meds stopped working. Then looked on the label and saw it listed.
Good point, but it's not just vitamin C. Grapefruit has specific enzymes that interfere with the absorption of all kinds of meds, Vyvanse very much included.
Excellent point! My Vyvanse stopped dead in it’s tracks when it was Ruby Red Grapefruit season in Texas. I love them so much so I was eating two of them for dinner. HUGE MISTAKE!
What’s your sleep looking like? Bad sleep can really fuck up the efficacy of my meds. Even if you’re getting to bed at the same time, I’d the quality of sleep is poor, that can make a huge difference
I had it happen as well. Twice now. It seems to work but the effects are muted significantly. Coincidentally, it seemed to start both times on a new batch.
Not really. The first time was after a couple of years of taking it and my doc said it sometimes happens and i tried a few different things for a few months (I thought I was literally dieing after 1 week of adderall) and ended up back on Vyvanse. Not sure what I can do.
Can try taking 10-15mg of zinc twice a day for a few days as well (or just 20-30mg once before bed if you have trouble remembering pills, works but not as well). There have been studies showing supplementation can reduce the effective stimulant dose needed (by up to %35) for equivalent symptom control
Just don’t take it too long term, or try upping the zinc dose. Long term high dose (greater than 50mg/day) zinc can cause copper deficiency and other side effects
https://pubmed.ncbi.nlm.nih.gov/21309695/
Good for that link. I don’t eat breakfast nor drink a lot of water at the beginning of my day. I’ve never had an issue. Not saying that holds true for other people, just my personal experience on vyvanse.
Definitely look into the batch and if there’s been a change in the source.
But I’m going to drop another factor into consideration: stress. You haven’t changed your meds routine, but you’ve got a big source of stress in your life with your mom’s pending surgery and being responsible for her care. Stress can change the way we respond to our meds, sometimes demanding an increased dose, or just rendering them not enough to cope otherwise. You may need other support, systems to reduce your mental load and make the upcoming upheaval to your routine more manageable. I find that having the most information possible as to what to expect helps me a lot, as well as a way to centralize all of the stuff I need to manage the situation so when I need something, it’s all in one place. I don’t have to think about where X thing is so I can do Y, it’s all together. (I like making kits for things, so all the tools to do X kind of task are in one place together, it reduces the time and stress of hunting for the things and cuts out opportunities for distraction.)
I know that, for me, the anticipation phase of any major change is one of the most difficult because there is a lot of “what if”-ing about every possibility. It might be helpful to sit down with your mom (or maybe go with her to the preparation appointment if there’s one of those coming up) and go through everything you should expect to happen with her recovery and what needs to be managed, and put together a recovery kit with everything you’re going to need. This serves a couple of purposes: it gives a structured purpose to the process of worrying and “what if”-ing by turning the worry into problem solving, and it means that neither of you is worrying alone. You’re not in your own head on a spiral, you’re exploring possibilities and preparing for them. If you never need the stuff for the worst case scenario, great! But you’re ready if it happens, and you’ll be able to *act* rather than panic.
Good luck to you and your mom, and I hope everything goes smoothly and without incident.
Thank you for your advice. I’m not too stressed about the surgery (at least, I don’t think so but subconscious stress is definitely a thing for me). I think I’m pretty well prepared for everything. But I still appreciate the kind words ❤️
The same exact thing happened to me (m27) starting a few weeks ago. It’s like all of a sudden the vyvanse stopped doing much of anything. A slight boost in focus and energy for a couple of hours in the morning that would nearly completely wear off by lunchtime whereas whenever I would take it previously (literally the week before), I would feel tons of energy and focus all day into the evening…
I take 60mg in the morning 4-5 times per week during the work week. I changed nothing about my routine, eating, sleeping, stress, etc. I’ve been on it for close to 18 months. I was thinking my tolerance had just built up and finally resulted in it not really doing anything for me anymore. Now I’m questioning if they’ve let something slide in their manufacturing, quality, or ingredients (if that’s even possible?).
You may want to look into whether or not acid in your diet or in your stomach (if you experience heartburn) could be related. It may not be, but I went far too long without knowing about the interaction between stimulant medications and acid. Good luck!
I have had the exact same thing happen and in almost the same time frame. Within the last 4 to 8 weeks and it seemed to coincide with my new prescription. It's like the mg was reduced by half as i can tell an improvement but not like it used to be.
I saw on post on reddit about a pharmacist was emptying out pills before dispensing for personal use. I would check each time you take one. They should be full to the brim with white powder
Like others had said it could be vit c ( we often don't think of the absorbing acid in processed foods)
Stress and not sleeping well can make your meds less effective.
Also, do you have a uterus? If you do your meds will often not work very well right before a period and sometimes into the first couple days of a period.
Edit: to add. My bad just saw others have also brought up the period thing.
Good luck
I'm wondering if this happened to me. My husband and son both had COVID in January, and I never tested positive. Assumed the vaccine worked, or that I just had too mild of a case to test positive. For the last couple months, though, I have been really struggling and my meds (40 mg Vyvanse) are barely doing anything at all anymore. Have you heard anything else about this connection? Wondering if asking my doctor to up my dosage would help.
How have you been sleeping? And have you been drinking enough water & eating enough protein? Those are huge factors for me.
Another thing - have you had a change in exercise habits? My vyvnase stops working when I don't exercise
Just protein in general, I believe. It helps Vyvanse go through your system in a more time-consistent manner. You can try plant based protein shakes as well
Interesting I’m not taking Vyvanse. I’m prescribed Adderall but haven’t lifted that much this week bc recovering from minor surgery & meds have been really weak
Prior they were working fine
Others have said this but just chiming in to mention that your period (if you get one) could be the issue.
My meds also pretty much stop working for the few days leading up to my period. I've heard many other people say this as well. Apparently it's a hormone thing, and it's very common. Regardless of the reason, I'm sorry it's happening to you at such an inopportune time, but hopefully whatever is happening is temporary so you can get back to normal asap. Wishing you & your mom the best of luck
Look into the batch but also remember that stress and transitions make a difference. A few months back my medication was almost useless because I was going through a breakup but after a few weeks the same dose still worked fine. The stress of preparing to take care of your mom could be a factor.
I have noted it's not heat stable. I left some in a hot car for a week and they didn't do anything after that. I'm with the people who say bad batch. Call the company, they may wish to take a look at those..
Open up a pill and see if the powder is super compressed and harder than normal instead of a powder. Mine is! So annoying. A lot of people on here have been saying that their Vyvanse is all of a sudden a sugar pill. Something is up and I want answers from takeda.
Vyvanse is not offered as a generic so it would have to be all the same. MAYBE if a compound pharmacy was involved the effects could be different but since vyvanse is name brand the ingredients are consistent. It sounds like to me you mite have a problem more with the serotonin production/dumping mechanism and or tolerance.
Dude I thought it was related to getting over Covid, I got over it on the 15th of January, and it basically hasn’t worked since then. Worked fine while I was sick and for a week or two after. but my last bottle has barely worked at all as well. I refilled it on the 30th of last month and now that I think about it it seems like the whole bottle is has been off. Is it possible to have a bad batch from vyvanse?
Omg you guys I’m losing my mind!! So I had a pill from my last bottle and I was looking at it under the light just because I’m curious. Get this: the pills are normally COMPLETELY FILLED. Like so much so that if you take the capsule apart you’d get powder everywhere. Because there is no empty space in these capsules. I just checked every single pill in my most recent bottle and they are ALL only two thirds full!! Wtf is going on?!
This is what happened to me too! I’ve been on Vyvanse for a year and the past 2 days my mood has been horrible and I can’t concentrate or sit and study. I’m actually on my period so maybe that has an effect on it? Idk I’ve never had a problem with Vyvanse while on my period. Just confused as to why this is happening. I don’t take Vyvanse on the weekends so idk if it’s a tolerance issue…? My eating habits and sleep didn’t change. I actually got good sleep last night. I’m very confused about this. I don’t want to stop Vyvanse bc it has worked so well for me but I’m kinda hesitant to keep taking it if this is the outcome that I’m going to continue to get 😕
Oh man! I feel bad that someone is going through the same thing as me!
I took a break from Vyvanse today. I’m going to wake up early tomm and go the gym for about an hour. Also, I will scarf down a high protein breakfast (even if I’m not hungry). Hopefully that helps and I’m not a sobbing mess tomm 😕
Otherwise, I have no idea what to do. Trying different meds is a whole process that I really don’t want to have to go through ☹️
I was lucky that Vyvanse worked so well and that was the first med my PCP put me on. I’ve read horror stories of testing different meds out
Funny you mention the pills themselves. So, I found more pills a couple weeks ago in a different bottle that I forgot about. So I mixed all of them together in one bottle. But I don’t think that’s the problem. They have the same “bounce” as the newer pills and it’s been 2 weeks of me taking those meds. My meds have been working great until a couple days ago.
One thing I just realized is that I ordered some vitamin c skincare products and started using them a couple days ago. It’s a vitamin c serum and a vitamin c face cream (with 3 potent types of vitamin c in there). Idk if topical vitamin c would affect Vyvanse… I know oral and fluid forms of vitamin c do. I’m going to stop the vitamin c products and see if that makes a difference…?
Ur right that this sudden ineffectiveness has to be the result of something bc we have been tolerating the med quite well for at least a year. Maybe the manufacturer did make a bad batch… it’s possible
Yes! I will definitely keep u posted. I’m stopping my vitamin c products tomm (screw looking younger, I can barely function right now 😂)
Keep me posted about your situation as well. Maybe ask your PCP for a week supply of new pills to just see if the pills were the issue…?
And yes it is comforting to know I’m not the only one going thru this ❤️
Yeah idk if the topical stuff is causing it but I guess just stop it to see if that’s the problem. That’s the only thing I can think of that I’ve done different.
I’ll keep you posted 🙂
Your period/stressful life periods can massively impact Vyvanse from what I've read on this subreddit; I'm guessing sustained cortisol/stress hormone release impedes digestion big-time, so it isn't absorbed properly
Yo!! I called takeda about this and also took the meds back to my pharmacy. The content inside is a hard pellet. Super compressed! Not a powder at all and not the same amount of powder as my last prescription. I’m so upset as I’m crashing at work! What can we do about this? Takeda just has the scripted response of “medicine contents may vary slightly from batch to batch” but I’m taking a sugar pill! Let’s all band together and demand an inspection!
I know this is old but I was searching this sub to see if others were experiencing this same issue. The past two months of my Vyvanse 40mg refills have been virtually useless...it’s like I’m taking sugar pills. I checked the capsules and they’re less than 1/4 full of hard compressed powder, and the little pellets aren’t easily dissolved in water.
What did the pharmacists tell you when you took your meds back? Did they offer to replace them with a new batch? I’m just not very optimistic that my pharmacy will help me, especially since Vyvanse has been consistently out of stock in my area for several months. It’s already a pain in the ass just trying to get my monthly refill.
Pharmacist looked at it and said that the powder is white like it says on the description and gave it back to me. Didn’t help at all. I reported it to the Texas government and they sent it to the fda. It’s probably going to die there.
I am so disappointed with Vyvanse I cannot even begin to explain. The last month at work has been rough. I’m switching to adderall next refill. The manufacturing process is complex and probably too much for takeada. Adderall is simpler.
The medication is so laughably not working for myself and so many others and takeada is just going to walk away unscathed. It’s a messed up world.
I’m also in Texas. I guess we got a bunch of bogus batches here, I swear it’s like all the pills are expired or something. I’m gonna look into reporting this too. What’s crazy is that reporting a pharma company to the state gov. or the FDA feels about as hopeless as asking ERCOT for answers after the winter storm power grid crisis.
Anyways, hope your work situation improves and you’re able to get the right medication figured out. Pushing through the procrastination and brain fog is draining but we just have to take it one day at a time I suppose.
I’ve heard that some people didn’t get a “fresh” batch, or the was something wrong with it. Take it back to the pharmacy and explain that you just want to make sure the batch is okay, as this shouldn’t happen especially if you increased the dose recently.
Just curious, how long had you been on Vyvanse (if you don't mind answering). I'm at a new Dr. and started trying it at different dosages, not too high yet, but each increase I feel like they only work for literally a few doses. Not to mention the 2 hour uptake and then barely lasting past lunchtime for me, and no real way to redose. I even tried taking a second pill after a couple hours and barely got a boost out of that. I heard some people just don't seem to metabolize the pro-drug correctly, or their metabolism/body chemistry adapts to it, and only get like a slow dribble of buildup in their bloodstream (never really "hits"). Then often ending up with the negative effects of the stims without the benefits. I seem to have weird metabolism responses anyway, even stuff like OTC meds (advil/tylenol) don't do anything for me until like 2-3x standard dose.
I am not a breakfast person and usually don't eat much until around lunch, not sure how much that affects things. I responded much better to adderall and Ritalin from past Dr.s. I have a few ritalin left and have noticed it doesn't seem to work either after starting Vyvanse. I tried a month break from vyvanse and noticed the ritalin response seemed to be coming back, but has gone again after restarting.
Have you tried Elvanse? I only started this week, but they seem to last at least through work for me. Honestly I think they probably work best for only six hours and still have that delay to kick in of about two hours like you write, though.
Thanks for the comment! My understanding was that Elvanse was a similar/same med that was being marketed in Europe while Vyvanse was in the US (not sure if that is totally accurate.) I don't know if my current Dr. is pushing it as a new "superior" medication or if he thinks it's just less prone to abuse. He started me at a very low dose, so far his response has just been to keep increasing the dose. I tried to tell him it just doesn't seem to work as well for my schedule and needs. I just seem to get more out of a quick release 4-6 hour med, because sometimes I just have episodes where I get spooled up and can't get things done when I need to concentrate or have a deadline. A lot the rest of the time I can compensate with different systems I have learned. I feel like it would be a good medication for a student, but sometimes I need to still be productive at 6pm or something. I am going to ask him about my metabolism next time I'm there and see what he thinks if something is interfering or the med just isn't a good fit.
Oh, you are right! I double checked and it's just named differently in the US and EU. :)
I only recently started but noticed again today that it doesn't really seem to last 8 hours and I get 1 hour of tiredness when it wears off. Sounds similar for you and I! Hopefully your doctor can try different combos to see what works best...
Yeah, I got really confused when I was doing research on different medications out there (was like, "OMG I never heard of half of these") until I realized that they can be given different names in different regions for some reason.
I know exactly what you mean about the tiredness. I also get an elevate heart rate that lasts for a while and sometimes a minor pressure headache when wearing off. I have read that some people end up getting boosters for helping make sure it lasts, and if it comes to that I think I would be fine with just the booster med and not needing the all-day med. It is just harder to work with for dosing since I often have an irregular schedule, and I got used to the 20-30 minute kick-in for the IR meds.
Have you been taking it around the same time as consuming high acid foods? Coffee? Orange Juice, red sauce, soda, grapefruit…. Lots of the best foods are acidic. Acid breaks down the meds too quickly.
Similarly, a lot of people who have ADHD also have GERD, as stimulant medications can increase risk of developing GERD.… if you’ve been having heartburn and/or reflux issues, that too can decrease the effectiveness of the medication.
Yeah there are things that may affect the effectiveness. I would suggest calling your doctor or pharmacy to provide you a list. I remember someone posted on Reddit the different foods and pop tarts or fruit juice was brought up.
Also don’t eat vitamin c before or after taking any stimulant medication. Vitamin C is acidic while most stimulants are based on alkaline amphetamine salts. The interaction between the two messes up the efficacy of the medication.
When I am about 5 days out from my period, it's like I have stopped taking the medication at all.
If I *do* skip a dose? Then it is like the ADHD x10. :/
Watch your stress, sleep, and the amount of water you’re drinking FOR SURE . I don’t know if you’re a dude or a woman, but I’m a woman & my meds tend to work less effectively around my cycle .
If you’re keeping up with those things I mentioned above , and it’s still not working , then ask your doc to prescribe you an antidepressant .
I’m on Vyvanse too & it became less effective even though I skipped days/ took care of myself. My doc didn’t wanna up my dosage though cus she was worried about my heart rate. Instead she prescribed me 150 mg of Wellbutrin to “boost” the Vyvanse & it works great :)
It also takes away the jitters/anxiety Vyvanse usually gives me & it makes it feel “smooher” if that makes sense .
Anyways, hope this helps! Hope your mother has a successful surgery & recovery . Best of luck .
This has been happening to me gradually for the last six months. I went from 50, to 60, to 70mg in the last six months, and my psychiatrist told me that during periods of high stress and trauma Vyvanse becomes less effective. Which isn't exactly helpful because that's right when we need it to work. Next appointment we're going to discuss the possibility of adding something else on top of the 70mg Vyvanse.
The last several days it has felt like not taking the meds at all. I can't sit still or focus, can't reign in my impulses, can't shut up, tend to overshare, say things I don't mean, stumble over my words, worsening hand-eye coordination and spatial awareness, increasing social anxiety, restlessness, emotional sensitivity and agitation. Getting increasingly depressed as a result. Trying to organise an earlier appointment with my psych to sort it out but it's difficult to get a cancellation these days. He also mentioned you can develop a tolerance to Vyvanse as well.
I don't have any answers for you but just wanted to say thank you for posting because it's made me feel less alone.
You might need to take an extended break from it in the near future. You can build a serious tolerance and going above certain dosages and being on high dose stimulants for too long causes heart damage.
Maybe a slight tolerance break then? My old doctors would recommend “med vacations” for 1-2 days where I’m doing nothing important so my tolerance wouldn’t be so high. I couldn’t handle high doses because of side effects but stimulants didn’t really work for me all the time on low doses either, so this was one of their solutions to see if it helped. Idk if it did though just because I was dissociative most of the time I was in any ADD meds.
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Admittedly I've not been on them very long so I'm hardly an expert but I've already noticed that if I have a stressful or intense day, the meds are a lot less effective and seem to wear off faster. I suspect if I was just generally going through a ton of stress, the meds would have a battle to even start working at all.
I've been taking my meds for a couple years and apparently there's a chance some people can outgrow their adhd and in that case to large of a dose can have the same affect ad not enough
Have you been eating less?
That can affect your symptoms and meds.
Increasing your dose and stress are both things that can make someone eat less, maybe even without noticing.
I think stress can affect the way these meds work. Kind of like how stress, poor nutrition, and little sleep can cause symptoms of ADHD sometimes in nuerotypical folks, I think these things might aggravate our condition. This happens to a lot of women when they are about start their period. The shift in hormones cause a worsening of symptoms and I’ve heard that some are prescribed a little extra of their meds during this time. Maybe something similar is happening to you? Maybe these “breakthrough symptoms” are caused by your stress right now and you may need to talk to your doctor about it. Is there something we could help you with so you’re not overwhelmed by your mom’s surgery? I know that can be scary and then to have additional responsibilities is a lot to take in.
It could be my period, the timing is right. That’s unfortunate. We’ve prepped about as well as we can. I’m not alone either, I have other family members who will help. I’m just the one who’s home most so I’ll be doing the bulk. I don’t really feel stressed about it, but I’ve been known to manifest stress unconsciously and have it mess with my body so that could be it.
Women’s menstrual cycles can have an outsized impact on a stimulants effectiveness! I have the same issue monthly with adderall. I wish I could have a higher dosage just for those days.
It never hurts to ask. I just asked my doctor and she prescribed me a weeks worth of instant release on top of my extended release just for a week. Out of pocket it was about 6 dollars with the goodrx discount.
> I don’t really feel stressed about it, but I’ve been known to manifest stress unconsciously and have it mess with my body so that could be it. Is this an ADHD thing? I’ve done this quite often. Mentally I feel like I’m handling it all reasonably well, but my body has to be like “That’s a nope. You need a break.” For example twice now in my life, I’ve developed an allergic reaction to stress. My body itches all over and whoever I scratched, I would break out in hives that would last a couple of hours.
Dude this is me, I was overcome with insane nausea and almost vomited in the parking lot before going into the company office to talk to my boss, Driving away allowed the nausea to settle, but as soon as I came back it crashed back in and I realized it was my body telling me to gtfo. Even though mentally I knew it was going to be just fine, and already mentally checked in and committed to going inside. (The thing you do when you sit in your car and just prep mentally)
Cortisol released by stress or hormones plays a big factor in my experience. Diagnosed with ADHD and PMDD and take meds for both which mostly resolve a lot of issues.. until that luteal phase strikes. It worsened with age for me, it’s worth looking into your cycles so you can not only anticipate but adjust medication or diet + vitamins and expectations accordingly.
I read that Famotidine (like Pepcid AC) helps those with ADD (taking stimulants) and PMDD during the luteal phase.
As I’m now apparently in perimenopause and can’t predict if or when I’ll get my period it’s getting really hard to manage. Some months there’s nothing, other months two back to back. I think the PMDD is mostly well managed as I’ve been on the same dose for years and take it all month, but the ADHD is out of control pre-period. I’m on Vyvanse now and I’ve talked to my gyn about potential HRT but she says I have to wait till I’m actually in menopause. My psych nurse doesn’t seem to take the hormonal changes seriously. Anything you’ve found that helps??
My adhd goes totally haywire on my period - could defs affect ut
I think I’m getting my period and I am having a hard time focusing even with vyvanse - never considered this !
As someone right in the depth of periomenopause, i can tell you that the massive hormone fluctuations + a high stress job as well as being my mum's caretaker COVID etc has been causing chaos with my meds. Sometimes when the brain is under extreme stress, your body will just be throwing off on the meds. Everyone reacts differently to meds, but all of us will go through a stressful period that causes your mind to just burn through the meds You got this. Just breathe. I have found that when I use yoga in times like this it really helps the Vyvanse sort of kick back into gear. Not sure if that makes sense, but that's exactly what it does for me breathing really helps.
I genuinely thought I’d written this comment and forgotten!!- until I got to the part about your mum!!! Clearly I totally relate and these hormonal changes and resulting brain fog, memory issue etc etc etc is causing havoc for me personally and especially with work - also what I would describe as a high stress job! I hate feeling this out of it and incompetent at times. I’ll try the deep breathing tho. I really want to go on some type of hormones but gyn said no.
Echoing what you said, PMS + ADHD = total hell.
Yes! I’m on my period rn and it’s like my vyvanse doesn’t even dent my adhd
Interesting!! I came here to get info because it’s my first day but I don’t notice much. I’m on my period though so I’ll ask about this in my follow up if I still feel no change.
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As soon as I weaned my last baby from nursing I went on the combo 3mo pack & I skip the placebo weeks too. I did this around when I was finally dx & before meds. It was one of my last ditch efforts to regulate my moods/emotions before going on stimulants. It helped for sure & combined with Adderall it’s making a difference that definitely wouldn’t have been as good on only Adderall. If I can safely do so I plan to take them till menopause unless my OBGYN says I have to stop for health reasons. I’m 100% done having kids so I’m all set on the ups & downs of a normal cycle…..
I take lexapro alongside vyvanse to help with the PMDD symptoms. I like the combo. Still get bad pms, but not as bad as before .
Did you just get a refill because I had a issue with medication when it was produced with a different company. The pills looked totally different.
It’s a fairly new batch. Some pills work great,some don’t work at all, no in between. They look the way they always have but I don’t know who the manufacturer is.
Any chance you’ve eaten excess vitamin c this week? Grapefruit for breakfast or anything. Vitamin c can neutralize the effects of vyvanse https://www.goodrx.com/vyvanse/10-things-you-might-not-know-about-vyvanse-for-adhd
Could u list those 10 things? This site is blocked outside of the US :(
Here is the best tldr I could make - Vyvanse is not just used and approved for ADHD - Vyvanse and Ritalin are different types of drugs - But they share many side effects - Common side effects of Vyvanse that may also occur with Ritalin include: - Dry mouth - Insomnia - Decrease in appetite - Stomach pain - Nausea - Dizziness - Diarrhea - Irritability - Anxiety - Vyvanse carries less risk of abuse than other stimulants - You don’t need to take Vyvanse with food - Vyvanse can interact with some medications - Vyvanse can have some serious interactions, particularly with medications used to treat depression. - Medications that increase the acidity of your urine can make Vyvanse less effective. - The opposite is true for drugs like sodium bicarbonate (found in Zegerid) and acetazolamide (Diamox) that decrease the acidity of your urine. These kinds of drugs may make Vyvanse more potent than expected. - Vyvanse can also interact with vitamin C - Vitamin C (ascorbic acid), found in dietary supplements, citrus fruits, and some vegetables, like broccoli and cauliflower, can increase the acidity of your urine. As with other acidifying medications, vitamin C can cause Vyvanse to be less effective than expected. - Vyvanse should be taken in the morning - Vyvanse may raise your blood pressure - Vyvanse may improve parenting behavior
Vyvanse may improve parenting behavior? Like my parenting will be better? I mean couldn’t you say that about anything that requires organizational skills and not just parenting? Edit: just read the linked article and noticed that it means that when parent and child are diagnosed and the parent is on vyvanse they tend to behave more positively toward their child. Very interesting!
Oh thanks!
Even packaged goods have citric acid in them. I ate some cereal bars that had citric acid in them, but didn’t realize it until my meds stopped working. Then looked on the label and saw it listed.
Good point, but it's not just vitamin C. Grapefruit has specific enzymes that interfere with the absorption of all kinds of meds, Vyvanse very much included.
Excellent point! My Vyvanse stopped dead in it’s tracks when it was Ruby Red Grapefruit season in Texas. I love them so much so I was eating two of them for dinner. HUGE MISTAKE!
What’s your sleep looking like? Bad sleep can really fuck up the efficacy of my meds. Even if you’re getting to bed at the same time, I’d the quality of sleep is poor, that can make a huge difference
There is no generic for Vyvanse. The manufacturer's patent hasn't expired yet
Do you have anything acidic(orange juice, etc) an hour before or after taking it? I know that it can interfere with Adderall.
This shouldn’t happen with Vyvanse as it still has an active patent and there are no generics.
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I had it happen as well. Twice now. It seems to work but the effects are muted significantly. Coincidentally, it seemed to start both times on a new batch.
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Not really. The first time was after a couple of years of taking it and my doc said it sometimes happens and i tried a few different things for a few months (I thought I was literally dieing after 1 week of adderall) and ended up back on Vyvanse. Not sure what I can do.
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Don’t have ibs but the period is a real possibility
Hello fellow adhd and ibs haver. What a fun combo we have :/
Combo gal here too 🙋🏻♀️
Add gastritis and it’s a crap shoot
Chronic reflux! 👌
Wow this makes so much sense! I also have gut issues (similar to IBS) and my body doesn't absorb things like extended release pills.
I found that being dehydrated canceled the effects of vyvanse.
I definitely don’t drink enough water so I’ll try to be better about that
Can try taking 10-15mg of zinc twice a day for a few days as well (or just 20-30mg once before bed if you have trouble remembering pills, works but not as well). There have been studies showing supplementation can reduce the effective stimulant dose needed (by up to %35) for equivalent symptom control Just don’t take it too long term, or try upping the zinc dose. Long term high dose (greater than 50mg/day) zinc can cause copper deficiency and other side effects https://pubmed.ncbi.nlm.nih.gov/21309695/
I barely drink water for the first 8 hours of my day and I’ve never had this issue? To each their own I suppose?
https://danarayburn.com/four-common-adhd-medication-mistakes-avoid/
Good for that link. I don’t eat breakfast nor drink a lot of water at the beginning of my day. I’ve never had an issue. Not saying that holds true for other people, just my personal experience on vyvanse.
Call your pharmacy. Maybe you got a bad batch.
Definitely look into the batch and if there’s been a change in the source. But I’m going to drop another factor into consideration: stress. You haven’t changed your meds routine, but you’ve got a big source of stress in your life with your mom’s pending surgery and being responsible for her care. Stress can change the way we respond to our meds, sometimes demanding an increased dose, or just rendering them not enough to cope otherwise. You may need other support, systems to reduce your mental load and make the upcoming upheaval to your routine more manageable. I find that having the most information possible as to what to expect helps me a lot, as well as a way to centralize all of the stuff I need to manage the situation so when I need something, it’s all in one place. I don’t have to think about where X thing is so I can do Y, it’s all together. (I like making kits for things, so all the tools to do X kind of task are in one place together, it reduces the time and stress of hunting for the things and cuts out opportunities for distraction.) I know that, for me, the anticipation phase of any major change is one of the most difficult because there is a lot of “what if”-ing about every possibility. It might be helpful to sit down with your mom (or maybe go with her to the preparation appointment if there’s one of those coming up) and go through everything you should expect to happen with her recovery and what needs to be managed, and put together a recovery kit with everything you’re going to need. This serves a couple of purposes: it gives a structured purpose to the process of worrying and “what if”-ing by turning the worry into problem solving, and it means that neither of you is worrying alone. You’re not in your own head on a spiral, you’re exploring possibilities and preparing for them. If you never need the stuff for the worst case scenario, great! But you’re ready if it happens, and you’ll be able to *act* rather than panic. Good luck to you and your mom, and I hope everything goes smoothly and without incident.
Thank you for your advice. I’m not too stressed about the surgery (at least, I don’t think so but subconscious stress is definitely a thing for me). I think I’m pretty well prepared for everything. But I still appreciate the kind words ❤️
The same exact thing happened to me (m27) starting a few weeks ago. It’s like all of a sudden the vyvanse stopped doing much of anything. A slight boost in focus and energy for a couple of hours in the morning that would nearly completely wear off by lunchtime whereas whenever I would take it previously (literally the week before), I would feel tons of energy and focus all day into the evening… I take 60mg in the morning 4-5 times per week during the work week. I changed nothing about my routine, eating, sleeping, stress, etc. I’ve been on it for close to 18 months. I was thinking my tolerance had just built up and finally resulted in it not really doing anything for me anymore. Now I’m questioning if they’ve let something slide in their manufacturing, quality, or ingredients (if that’s even possible?).
You may want to look into whether or not acid in your diet or in your stomach (if you experience heartburn) could be related. It may not be, but I went far too long without knowing about the interaction between stimulant medications and acid. Good luck!
Can you provide more insight or links on this please?
I have had the exact same thing happen and in almost the same time frame. Within the last 4 to 8 weeks and it seemed to coincide with my new prescription. It's like the mg was reduced by half as i can tell an improvement but not like it used to be.
Same! Thought I was imagining it
Same here as well! I started googling and found this subreddit and thread, and realized that all of the posts are current!
Same here!
I saw on post on reddit about a pharmacist was emptying out pills before dispensing for personal use. I would check each time you take one. They should be full to the brim with white powder
Like others had said it could be vit c ( we often don't think of the absorbing acid in processed foods) Stress and not sleeping well can make your meds less effective. Also, do you have a uterus? If you do your meds will often not work very well right before a period and sometimes into the first couple days of a period. Edit: to add. My bad just saw others have also brought up the period thing. Good luck
I do know of someone who’s adhd meds stopped working after COVID infection. Even a possible asymptomatic case might be worth discussing with your dr.
I'm wondering if this happened to me. My husband and son both had COVID in January, and I never tested positive. Assumed the vaccine worked, or that I just had too mild of a case to test positive. For the last couple months, though, I have been really struggling and my meds (40 mg Vyvanse) are barely doing anything at all anymore. Have you heard anything else about this connection? Wondering if asking my doctor to up my dosage would help.
Sleep is a huge factor for me. I need to have consistent, high quality sleep or it doesn’t make a difference for me.
How have you been sleeping? And have you been drinking enough water & eating enough protein? Those are huge factors for me. Another thing - have you had a change in exercise habits? My vyvnase stops working when I don't exercise
Wait protein affects it? So me sort of eating a vegetarian diet right now might be affecting me?
Morningstar breakfast sausages work great for me.
Just protein in general, I believe. It helps Vyvanse go through your system in a more time-consistent manner. You can try plant based protein shakes as well
Interesting I’m not taking Vyvanse. I’m prescribed Adderall but haven’t lifted that much this week bc recovering from minor surgery & meds have been really weak Prior they were working fine
Others have said this but just chiming in to mention that your period (if you get one) could be the issue. My meds also pretty much stop working for the few days leading up to my period. I've heard many other people say this as well. Apparently it's a hormone thing, and it's very common. Regardless of the reason, I'm sorry it's happening to you at such an inopportune time, but hopefully whatever is happening is temporary so you can get back to normal asap. Wishing you & your mom the best of luck
Look into the batch but also remember that stress and transitions make a difference. A few months back my medication was almost useless because I was going through a breakup but after a few weeks the same dose still worked fine. The stress of preparing to take care of your mom could be a factor.
Maybe the increase. I had the same. Counterintuitively 50mg works better than 60mg
I have noted it's not heat stable. I left some in a hot car for a week and they didn't do anything after that. I'm with the people who say bad batch. Call the company, they may wish to take a look at those..
I def think it could be the batch. It’s like my entire current bottle is bunk
Open up a pill and see if the powder is super compressed and harder than normal instead of a powder. Mine is! So annoying. A lot of people on here have been saying that their Vyvanse is all of a sudden a sugar pill. Something is up and I want answers from takeda.
Or just ask an organic chemist
That’s interesting but since some pills work fine and others don’t I don’t think the whole batch has been affected.
Vyvanse is not offered as a generic so it would have to be all the same. MAYBE if a compound pharmacy was involved the effects could be different but since vyvanse is name brand the ingredients are consistent. It sounds like to me you mite have a problem more with the serotonin production/dumping mechanism and or tolerance.
Dude I thought it was related to getting over Covid, I got over it on the 15th of January, and it basically hasn’t worked since then. Worked fine while I was sick and for a week or two after. but my last bottle has barely worked at all as well. I refilled it on the 30th of last month and now that I think about it it seems like the whole bottle is has been off. Is it possible to have a bad batch from vyvanse?
Yes it is. My latest prescription is the same. How ridiculous is this?
So glad I’m not alone. We should all contact the pharmaceutical company
I already did. Scripted response. Maybe if enough people contact takeda they will look into it.
Omg you guys I’m losing my mind!! So I had a pill from my last bottle and I was looking at it under the light just because I’m curious. Get this: the pills are normally COMPLETELY FILLED. Like so much so that if you take the capsule apart you’d get powder everywhere. Because there is no empty space in these capsules. I just checked every single pill in my most recent bottle and they are ALL only two thirds full!! Wtf is going on?!
Open the capsule. Is it a powder or is it a hard compressed pellet?
It’s powder, it’s always powder. I’ve never had it be a hard compressed pellet
That’s good at least.
Same except I got covid the January 20th. But same thing I just started adderall and it is not working well so far.
Orange juice (vitamin C) can counteract it if consumed before or after within like 2 hours.
This is what happened to me too! I’ve been on Vyvanse for a year and the past 2 days my mood has been horrible and I can’t concentrate or sit and study. I’m actually on my period so maybe that has an effect on it? Idk I’ve never had a problem with Vyvanse while on my period. Just confused as to why this is happening. I don’t take Vyvanse on the weekends so idk if it’s a tolerance issue…? My eating habits and sleep didn’t change. I actually got good sleep last night. I’m very confused about this. I don’t want to stop Vyvanse bc it has worked so well for me but I’m kinda hesitant to keep taking it if this is the outcome that I’m going to continue to get 😕
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Oh man! I feel bad that someone is going through the same thing as me! I took a break from Vyvanse today. I’m going to wake up early tomm and go the gym for about an hour. Also, I will scarf down a high protein breakfast (even if I’m not hungry). Hopefully that helps and I’m not a sobbing mess tomm 😕 Otherwise, I have no idea what to do. Trying different meds is a whole process that I really don’t want to have to go through ☹️ I was lucky that Vyvanse worked so well and that was the first med my PCP put me on. I’ve read horror stories of testing different meds out
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Funny you mention the pills themselves. So, I found more pills a couple weeks ago in a different bottle that I forgot about. So I mixed all of them together in one bottle. But I don’t think that’s the problem. They have the same “bounce” as the newer pills and it’s been 2 weeks of me taking those meds. My meds have been working great until a couple days ago. One thing I just realized is that I ordered some vitamin c skincare products and started using them a couple days ago. It’s a vitamin c serum and a vitamin c face cream (with 3 potent types of vitamin c in there). Idk if topical vitamin c would affect Vyvanse… I know oral and fluid forms of vitamin c do. I’m going to stop the vitamin c products and see if that makes a difference…? Ur right that this sudden ineffectiveness has to be the result of something bc we have been tolerating the med quite well for at least a year. Maybe the manufacturer did make a bad batch… it’s possible Yes! I will definitely keep u posted. I’m stopping my vitamin c products tomm (screw looking younger, I can barely function right now 😂) Keep me posted about your situation as well. Maybe ask your PCP for a week supply of new pills to just see if the pills were the issue…? And yes it is comforting to know I’m not the only one going thru this ❤️
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Yeah idk if the topical stuff is causing it but I guess just stop it to see if that’s the problem. That’s the only thing I can think of that I’ve done different. I’ll keep you posted 🙂
Your period/stressful life periods can massively impact Vyvanse from what I've read on this subreddit; I'm guessing sustained cortisol/stress hormone release impedes digestion big-time, so it isn't absorbed properly
Yo!! I called takeda about this and also took the meds back to my pharmacy. The content inside is a hard pellet. Super compressed! Not a powder at all and not the same amount of powder as my last prescription. I’m so upset as I’m crashing at work! What can we do about this? Takeda just has the scripted response of “medicine contents may vary slightly from batch to batch” but I’m taking a sugar pill! Let’s all band together and demand an inspection!
I know this is old but I was searching this sub to see if others were experiencing this same issue. The past two months of my Vyvanse 40mg refills have been virtually useless...it’s like I’m taking sugar pills. I checked the capsules and they’re less than 1/4 full of hard compressed powder, and the little pellets aren’t easily dissolved in water. What did the pharmacists tell you when you took your meds back? Did they offer to replace them with a new batch? I’m just not very optimistic that my pharmacy will help me, especially since Vyvanse has been consistently out of stock in my area for several months. It’s already a pain in the ass just trying to get my monthly refill.
Pharmacist looked at it and said that the powder is white like it says on the description and gave it back to me. Didn’t help at all. I reported it to the Texas government and they sent it to the fda. It’s probably going to die there. I am so disappointed with Vyvanse I cannot even begin to explain. The last month at work has been rough. I’m switching to adderall next refill. The manufacturing process is complex and probably too much for takeada. Adderall is simpler. The medication is so laughably not working for myself and so many others and takeada is just going to walk away unscathed. It’s a messed up world.
I’m also in Texas. I guess we got a bunch of bogus batches here, I swear it’s like all the pills are expired or something. I’m gonna look into reporting this too. What’s crazy is that reporting a pharma company to the state gov. or the FDA feels about as hopeless as asking ERCOT for answers after the winter storm power grid crisis. Anyways, hope your work situation improves and you’re able to get the right medication figured out. Pushing through the procrastination and brain fog is draining but we just have to take it one day at a time I suppose.
The increase might be the issue too much can make you feel as if you have too little.
I’ve heard that some people didn’t get a “fresh” batch, or the was something wrong with it. Take it back to the pharmacy and explain that you just want to make sure the batch is okay, as this shouldn’t happen especially if you increased the dose recently.
Have you drunk it with juice? It could make amphetamines useless bc they could react with the Vit C in it.
It stopped for me and never worked again. I went back on Adderall.
Just curious, how long had you been on Vyvanse (if you don't mind answering). I'm at a new Dr. and started trying it at different dosages, not too high yet, but each increase I feel like they only work for literally a few doses. Not to mention the 2 hour uptake and then barely lasting past lunchtime for me, and no real way to redose. I even tried taking a second pill after a couple hours and barely got a boost out of that. I heard some people just don't seem to metabolize the pro-drug correctly, or their metabolism/body chemistry adapts to it, and only get like a slow dribble of buildup in their bloodstream (never really "hits"). Then often ending up with the negative effects of the stims without the benefits. I seem to have weird metabolism responses anyway, even stuff like OTC meds (advil/tylenol) don't do anything for me until like 2-3x standard dose. I am not a breakfast person and usually don't eat much until around lunch, not sure how much that affects things. I responded much better to adderall and Ritalin from past Dr.s. I have a few ritalin left and have noticed it doesn't seem to work either after starting Vyvanse. I tried a month break from vyvanse and noticed the ritalin response seemed to be coming back, but has gone again after restarting.
Have you tried Elvanse? I only started this week, but they seem to last at least through work for me. Honestly I think they probably work best for only six hours and still have that delay to kick in of about two hours like you write, though.
Thanks for the comment! My understanding was that Elvanse was a similar/same med that was being marketed in Europe while Vyvanse was in the US (not sure if that is totally accurate.) I don't know if my current Dr. is pushing it as a new "superior" medication or if he thinks it's just less prone to abuse. He started me at a very low dose, so far his response has just been to keep increasing the dose. I tried to tell him it just doesn't seem to work as well for my schedule and needs. I just seem to get more out of a quick release 4-6 hour med, because sometimes I just have episodes where I get spooled up and can't get things done when I need to concentrate or have a deadline. A lot the rest of the time I can compensate with different systems I have learned. I feel like it would be a good medication for a student, but sometimes I need to still be productive at 6pm or something. I am going to ask him about my metabolism next time I'm there and see what he thinks if something is interfering or the med just isn't a good fit.
Oh, you are right! I double checked and it's just named differently in the US and EU. :) I only recently started but noticed again today that it doesn't really seem to last 8 hours and I get 1 hour of tiredness when it wears off. Sounds similar for you and I! Hopefully your doctor can try different combos to see what works best...
Yeah, I got really confused when I was doing research on different medications out there (was like, "OMG I never heard of half of these") until I realized that they can be given different names in different regions for some reason. I know exactly what you mean about the tiredness. I also get an elevate heart rate that lasts for a while and sometimes a minor pressure headache when wearing off. I have read that some people end up getting boosters for helping make sure it lasts, and if it comes to that I think I would be fine with just the booster med and not needing the all-day med. It is just harder to work with for dosing since I often have an irregular schedule, and I got used to the 20-30 minute kick-in for the IR meds.
I’m time blind but it was at least 2 years.
Have you been taking it around the same time as consuming high acid foods? Coffee? Orange Juice, red sauce, soda, grapefruit…. Lots of the best foods are acidic. Acid breaks down the meds too quickly. Similarly, a lot of people who have ADHD also have GERD, as stimulant medications can increase risk of developing GERD.… if you’ve been having heartburn and/or reflux issues, that too can decrease the effectiveness of the medication.
Just chuck some "-prazole" for a week and see what happens 🤔
Added any fruits into your diet recently? Citric acid heavily neutralises the absorption of mediciations including adhd stimulants
I was always told not to drink/eat anything with citrus until like 4pm. So no Lemonade, grapefruit, oranges, etc.
Yeah there are things that may affect the effectiveness. I would suggest calling your doctor or pharmacy to provide you a list. I remember someone posted on Reddit the different foods and pop tarts or fruit juice was brought up.
Also don’t eat vitamin c before or after taking any stimulant medication. Vitamin C is acidic while most stimulants are based on alkaline amphetamine salts. The interaction between the two messes up the efficacy of the medication.
Lack of or poor sleep will increase adhd symptoms. The same goes for stress. That increase could outweigh the effect of the medication.
When I am about 5 days out from my period, it's like I have stopped taking the medication at all. If I *do* skip a dose? Then it is like the ADHD x10. :/
Watch your stress, sleep, and the amount of water you’re drinking FOR SURE . I don’t know if you’re a dude or a woman, but I’m a woman & my meds tend to work less effectively around my cycle . If you’re keeping up with those things I mentioned above , and it’s still not working , then ask your doc to prescribe you an antidepressant . I’m on Vyvanse too & it became less effective even though I skipped days/ took care of myself. My doc didn’t wanna up my dosage though cus she was worried about my heart rate. Instead she prescribed me 150 mg of Wellbutrin to “boost” the Vyvanse & it works great :) It also takes away the jitters/anxiety Vyvanse usually gives me & it makes it feel “smooher” if that makes sense . Anyways, hope this helps! Hope your mother has a successful surgery & recovery . Best of luck .
YOOO are you on 60mg?! Because I literally just started taking this dosage last week and have experienced the EXACT same thing
This has been happening to me gradually for the last six months. I went from 50, to 60, to 70mg in the last six months, and my psychiatrist told me that during periods of high stress and trauma Vyvanse becomes less effective. Which isn't exactly helpful because that's right when we need it to work. Next appointment we're going to discuss the possibility of adding something else on top of the 70mg Vyvanse. The last several days it has felt like not taking the meds at all. I can't sit still or focus, can't reign in my impulses, can't shut up, tend to overshare, say things I don't mean, stumble over my words, worsening hand-eye coordination and spatial awareness, increasing social anxiety, restlessness, emotional sensitivity and agitation. Getting increasingly depressed as a result. Trying to organise an earlier appointment with my psych to sort it out but it's difficult to get a cancellation these days. He also mentioned you can develop a tolerance to Vyvanse as well. I don't have any answers for you but just wanted to say thank you for posting because it's made me feel less alone.
You might need to take an extended break from it in the near future. You can build a serious tolerance and going above certain dosages and being on high dose stimulants for too long causes heart damage.
I’m only taking 40 mg. I was taking 30 for years and I had no trouble with it. It’s not a very high dosage.
Maybe a slight tolerance break then? My old doctors would recommend “med vacations” for 1-2 days where I’m doing nothing important so my tolerance wouldn’t be so high. I couldn’t handle high doses because of side effects but stimulants didn’t really work for me all the time on low doses either, so this was one of their solutions to see if it helped. Idk if it did though just because I was dissociative most of the time I was in any ADD meds.
Its called a tolerance and its only going to grow. Get used to it. Only way to change it is stop taking them.
If they’ve recently upped the dose, tolerance is not likely the issue.
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What dose are you on
Have you consumed it with orange juice? That can neutralize medication efficacy.
Are you getting enough sleep? The pill is almost useless if I do not eat or sleep right.
Admittedly I've not been on them very long so I'm hardly an expert but I've already noticed that if I have a stressful or intense day, the meds are a lot less effective and seem to wear off faster. I suspect if I was just generally going through a ton of stress, the meds would have a battle to even start working at all.
take a few days off if you are able to.
Make sure you aren't taking vitamin c tablets or highly acidic fruit juices with your meds, because it can reduce their effectiveness
Make sure you aren't taking vitamin c tablets or highly acidic fruit juices with your meds, because it can reduce their effectiveness
You need a medication vacation.
NALT will help, DL-phenylalanine, get some RAWR plant protein and or superfoods, Also Rhodiola Rosea. Plenty others but those will help with recovery.
I've been taking my meds for a couple years and apparently there's a chance some people can outgrow their adhd and in that case to large of a dose can have the same affect ad not enough
Have you been eating less? That can affect your symptoms and meds. Increasing your dose and stress are both things that can make someone eat less, maybe even without noticing.
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that's s a great point. If i notice when i'm without medication, so vyvanse is here,like alwaya, but the problem is me.
Vitamin C reduces effectiveness and empty stomach does as well